MUSK

Gene Symbol	MUSK
Entrez Gene	4593
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	muscle, skeletal, receptor tyrosine kinase
Other Description	muscle, skeletal receptor tyrosine-protein kinase|muscle-specific kinase receptor|muscle-specific tyrosine-protein kinase receptor
Swissprots	O15146 Q5VZW7 Q32MJ8 Q32MJ9 Q5VZW8
Accessions	EAW59065 EAW59066 EAW59067 O15146 AA448972 AF006464 AAB63044 BC109098 AAI09099 BC109099 AAI09100 BG825304 EU832778 ACE87789 EU832779 ACE87790 GQ129313 ACT64447 Z25436 CAA80923 XM_005251994 XP_005252051 XM_005251995 XP_005252052 XM_005251996 XP_005252053 XM_011518707 XP_011517009 XM_011518708 XP_011517010 NM_001166280 NP_001159752 NM_001166281 NP_001159753 NM_005592 NP_005583
Function	Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylati
Subcellular Location	Cell junction, synapse, postsynaptic cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Localizes to the postsynaptic cell membrane of the neuromuscular junction. {ECO:0000305}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active MUSK protein fragment - ab71693 from Abcam Category Protein Prices $302.00 Sizes 10 µg Source Baculovirus infected sf9 cells

Human MUSK peptide - ab102603 from Abcam Category Peptide

Human MUSK protein fragment - ab152547 from Abcam Category Protein Source Wheat germ Species Human

MUSK Antibody Blocking Peptide - LS-E9164 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MUSK Antibody Blocking Peptide - LS-E9165 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MUSK Antibody Blocking Peptide - LS-E23011 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human MuSK Protein - H00004593-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

MuSK Recombinant Protein - P4729 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

MuSK Peptide - P2701 from Novus Biologicals Category Peptide Species Human

MuSK Peptide - P2700 from Novus Biologicals Category Peptide Species Human

MUSK-Antibody-C-term-Blocking-Peptide - BP7664b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MUSK-Antibody-N-term-Blocking-Peptide - BP7664a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human MUSK protein - orb244391 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human MUSK protein - orb245936 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human MUSK His GST tag (433-783) peptide - orb72181 from Biorbyt Category Peptide Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source Insect Species Human

MUSK - H00004593-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MUSK - H00004593-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MUSK - P4729 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

MUSK - P5732 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

MUSK fusion protein - ag16138 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

MUSK fusion protein - Ag17371 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

MUSK, Active Human Recombinant Protein - GWB-6FDFEA from Genway Biotech Category Protein Prices $410.00 Sizes 10 µg Species Human

Recombinant Human MUSK, GST-tagged, Active - MUSK-364H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus.

Recombinant Human MUSK, His & GST tagged - MUSK-959H from Creative Biomart Category Protein Source Baculovirus-Insect Cells Species Human

Recombinant Human MUSK - MUSK-30261TH from Creative Biomart Category Protein

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