Gene Symbol | NOL3 |
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Entrez Gene | 8996 |
Alt Symbol | ARC, FCM, MYP, NOP, NOP30 |
Species | Human |
Gene Type | protein-coding |
Description | nucleolar protein 3 (apoptosis repressor with CARD domain) |
Other Description | muscle-enriched cytoplasmic protein|nucleolar protein 3|nucleolar protein of 30 kDa |
Swissprots | O60937 B4DFL0 O60936 |
Accessions | AAC18590 AAC18591 EAW83087 EAW83088 EAW83089 O60936 AF043244 AAC34993 AF064599 AAC18593 AF064600 AAC18594 AK092623 AK294145 BAG57471 AK314899 BAG37413 BC012798 AAH12798 BF568452 BP215200 BQ685512 BT020158 AAV38960 CB959673 DA370107 DA928396 DQ893049 ABM83975 DQ896297 ABM87296 NM_001276319 NP_001263248 XM_005256217 XP_005256274 XM_005256219 XP_005256276 XM_006721322 XP_006721385 XM_006721323 XP_006721386 XM_011523424 XP_011521726 XM_011523425 XP_011521727 XM_011523426 XP_011521728 NM_001185057 NP_001171986 NM_001276307 NP_001263236 NM_001276309 NP_001263238 NM_001276311 NP_001263240 NM_001276312 NP_001263241 NM_003946 NP_003937 NM_001185058 NP_001171987 |
Function | Isoform 1: May be involved in RNA splicing. {ECO:0000269|PubMed:10196175}. |
Subcellular Location | Isoform 2: Cytoplasm {ECO:0000269|PubMed:10196175}. Mitochondrion {ECO:0000250|UniProtKB:Q62881}. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:Q62881}. Note=Phosphorylation at Thr-149 results in translocation to mithochondria. Colocalized with mitochondria in response to oxidative stress. {ECO:0000250|UniProtKB:Q62881}. |
Tissue Specificity | Highly expressed in heart and skeletal muscle. Detected at low levels in placenta, liver, kidney and pancreas. |
ARC CRISPR/Cas9 KO Plasmid (h) - sc-403704 from Santa Cruz Biotechnology
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ARC HDR Plasmid (h) - sc-403704-HDR from Santa Cruz Biotechnology
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ARC Double Nickase Plasmid (h) - sc-403704-NIC from Santa Cruz Biotechnology
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ARC Double Nickase Plasmid (h2) - sc-403704-NIC-2 from Santa Cruz Biotechnology
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ARC CRISPR Activation Plasmid (h) - sc-403704-ACT from Santa Cruz Biotechnology
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ARC CRISPR Activation Plasmid (h2) - sc-403704-ACT-2 from Santa Cruz Biotechnology
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ARC Lentiviral Activation Particles (h) - sc-403704-LAC from Santa Cruz Biotechnology
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ARC Lentiviral Activation Particles (h2) - sc-403704-LAC-2 from Santa Cruz Biotechnology
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ARC siRNA (h) - sc-29722 from Santa Cruz Biotechnology
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ARC shRNA Plasmid (h) - sc-29722-SH from Santa Cruz Biotechnology
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ARC shRNA (h) Lentiviral Particles - sc-29722-V from Santa Cruz Biotechnology
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ARC/NOL3 RNAi - H00008996-R01 from Novus Biologicals
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MISSION® esiRNA - EHU154181 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15399 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15399 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05638 from Sigma-Aldrich
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NOL3 siRNA (Human) - CRH5937 from Cohesion Biosciences
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shRNA set against Human NOL3 (NM_003946.4) - SHH353536 from Creative biogene
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Human NOL3 siRNA - orb266439 from Biorbyt
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NOL3 shRNA Plasmid (Human) - CHH5937 from Cohesion Biosciences
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NOL3 miRNA 3'UTR clone - MiUTR3H-07500 from Creative biogene
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