| Gene Symbol |
ATP1A4
|
| Entrez Gene |
480
|
| Alt Symbol |
ATP1A1, ATP1AL2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ATPase, Na+/K+ transporting, alpha 4 polypeptide
|
| Other Description |
ATPase, Na+/K+ transporting, alpha polypeptide-like 2|Na(+)/K(+) ATPase alpha-4 subunit|Na+/K+ ATPase 4|Na+/K+ ATPase, alpha-D polypeptide|Na,K-ATPase subunit alpha-C|sodium pump 4|sodium pump subunit alpha-4|sodium-potassium ATPase catalytic subunit alpha-4|sodium/potassium-transporting ATPase alpha-4 chain|sodium/potassium-transporting ATPase subunit alpha-4
|
| Swissprots |
Q8WXH7 Q8WXA7 Q7Z4I9 Q504T2 Q8TBN8 Q8WY13 Q13733
|
| Accessions |
AAK72396 AAL35818 AAM20793 EAW52737 EAW52738 Q13733 AF459737 AAL66357 AF506797 AAQ07964 AK098076 BAC05228 AK308286 AL833335 BC028297 AAH28297 BC036052 BC068570 BC094801 AAH94801 BX647234 DB094047 M16796 AAA51800 XM_011509582 XP_011507884 NM_001001734 NP_001001734 NM_144699 NP_653300
|
| Function |
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:16175638}; Multi-pass membrane protein {ECO:0000269|PubMed:16175638}. Note=In mature sperm, located in the principle piece of the sperm flagellum.
|
| Tissue Specificity |
Specifically expressed in testis. Found in very low levels in skeletal muscle. Expressed in mature sperm (at protein level).
|
| Top Pathways |
Salivary secretion, Cardiac muscle contraction, cAMP signaling pathway, Aldosterone-regulated sodium reabsorption, Thyroid hormone synthesis
|
