ATP1A4
| Gene Symbol | ATP1A4 |
|---|---|
| Entrez Gene | 480 |
| Alt Symbol | ATP1A1, ATP1AL2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ATPase, Na+/K+ transporting, alpha 4 polypeptide |
| Other Description | ATPase, Na+/K+ transporting, alpha polypeptide-like 2|Na(+)/K(+) ATPase alpha-4 subunit|Na+/K+ ATPase 4|Na+/K+ ATPase, alpha-D polypeptide|Na,K-ATPase subunit alpha-C|sodium pump 4|sodium pump subunit alpha-4|sodium-potassium ATPase catalytic subunit alpha-4|sodium/potassium-transporting ATPase alpha-4 chain|sodium/potassium-transporting ATPase subunit alpha-4 |
| Swissprots | Q8WXH7 Q8WXA7 Q7Z4I9 Q504T2 Q8TBN8 Q8WY13 Q13733 |
| Accessions | AAK72396 AAL35818 AAM20793 EAW52737 EAW52738 Q13733 AF459737 AAL66357 AF506797 AAQ07964 AK098076 BAC05228 AK308286 AL833335 BC028297 AAH28297 BC036052 BC068570 BC094801 AAH94801 BX647234 DB094047 M16796 AAA51800 XM_011509582 XP_011507884 NM_001001734 NP_001001734 NM_144699 NP_653300 |
| Function | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:16175638}; Multi-pass membrane protein {ECO:0000269|PubMed:16175638}. Note=In mature sperm, located in the principle piece of the sperm flagellum. |
| Tissue Specificity | Specifically expressed in testis. Found in very low levels in skeletal muscle. Expressed in mature sperm (at protein level). |
| Top Pathways | Salivary secretion, Cardiac muscle contraction, cAMP signaling pathway, Aldosterone-regulated sodium reabsorption, Thyroid hormone synthesis |
Na + /K + -ATPase α4 CRISPR/Cas9 KO Plasmid (h) - sc-402561 from Santa Cruz Biotechnology
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Na + /K + -ATPase α4 HDR Plasmid (h) - sc-402561-HDR from Santa Cruz Biotechnology
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Na + /K + -ATPase α4 Double Nickase Plasmid (h) - sc-402561-NIC from Santa Cruz Biotechnology
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Na + /K + -ATPase α4 Double Nickase Plasmid (h2) - sc-402561-NIC-2 from Santa Cruz Biotechnology
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Na + /K + -ATPase α4 CRISPR Activation Plasmid (h) - sc-402561-ACT from Santa Cruz Biotechnology
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Na + /K + -ATPase α4 CRISPR Activation Plasmid (h2) - sc-402561-ACT-2 from Santa Cruz Biotechnology
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Na + /K + -ATPase α4 Lentiviral Activation Particles (h) - sc-402561-LAC from Santa Cruz Biotechnology
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Na + /K + -ATPase α4 Lentiviral Activation Particles (h2) - sc-402561-LAC-2 from Santa Cruz Biotechnology
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Sodium Potassium ATPase Alpha 4 RNAi - H00000480-R04 from Novus Biologicals
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Sodium Potassium ATPase Alpha 4 RNAi - H00000480-R03 from Novus Biologicals
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MISSION® esiRNA - EHU014751 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3682 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3682 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02210 from Sigma-Aldrich
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ATP1A4 siRNA (Human) - CRH0336 from Cohesion Biosciences
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ATP1A4 - MBS8224319 from MyBioSource
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shRNA set against Human ATP1A4 (NM_144699.3) - SHH242542 from Creative biogene
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shRNA set against Human ATP1A4(NM_001001734.1) - SHG081313 from Creative biogene
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Human ATP1A4 siRNA - orb260838 from Biorbyt
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ATP1A4 shRNA Plasmid (Human) - CHH0336 from Cohesion Biosciences
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ATP1A4 miRNA 3'UTR clone - MiUTR1H-00677 from Creative biogene
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ATP1A4 miRNA 3'UTR clone - MiUTR1H-00678 from Creative biogene
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