PLA2R1

Gene Symbol PLA2R1
Entrez Gene 22925
Alt Symbol CLEC13C, PLA2-R, PLA2G1R, PLA2IR, PLA2R
Species Human
Gene Type protein-coding
Description phospholipase A2 receptor 1, 180kDa
Other Description 180 kDa secretory phospholipase A2 receptor|C-type lectin domain family 13 member C|M-type receptor|phospholipase A2 receptor 1, 180kD|secretory phospholipase A2 receptor
Swissprots D3DPB1 Q13019 Q15095 Q53R45 B2RTU9 Q53RR7 Q13018
Accessions AAY24052 AAY24190 CCQ43399 EAX11391 EAX11392 EAX11393 Q13018 AI672072 AL598405 BC140823 AAI40824 BC144631 AAI44632 BF725498 BF805380 BP351340 BQ025507 BQ637466 BX485732 D30780 BAA06444 U17033 AAA70110 U17034 AAC50163 W15508 XM_005246392 XP_005246449 XM_005246393 XP_005246450 XM_005246395 XP_005246452 XM_006712369 XP_006712432 XM_011510820 XP_011509122 XM_011510821 XP_011509123 XR_922892 NM_001007267 NP_001007268 NM_001195641 NP_001182570 NM_007366 NP_031392
Function Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2- IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2- IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow- derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPL
Subcellular Location Isoform 2: Secreted {ECO:0000305}.
Tissue Specificity Present in lung macrophage (at protein level). Highly expressed in kidney. Also expressed in pancreas, amnion, choriodecidua and placenta. Isoform 2 is expressed at much lower level. {ECO:0000269|PubMed:15611272, ECO:0000269|PubMed:7721806, ECO:0000269|PubMed:7925459, ECO:0000269|PubMed:9481783}.
Top Pathways Phagosome, Tuberculosis

Anti-PLA2R / PLA2R1 Antibody - LS-C144652 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PLA2R / PLA2R1 Antibody (C-Terminus) - LS-C144967 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PLA2R / PLA2R1 Antibody (C-Terminus) - LS-C153547 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PLA2R / PLA2R1 Antibody (aa385-643, Biotin) - LS-C300190 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PLA2R / PLA2R1 Antibody (aa385-643, FITC) - LS-C302476 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PLA2R / PLA2R1 Antibody (aa946-957) - LS-C108906 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
PLA2R1 antibody (1 ug/ml) staining of Human Ileum lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-PLA2R / PLA2R1 Antibody (aa385-643) - LS-C295908 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant PLA2R / PLA2R1.

PLA2R1 Antibody - NBP1-84449 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PLA2R1 Antibody [NBP1-84449] - Analysis in human kidney tissue.

PLA2R1 Antibody - NBP1-46116 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Monoclonal Anti-PLA2R1 antibody produced in mouse - AMAB90772 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone CL0474
<B>Immunohistochemistry</B><BR/>Monoclonal Anti-PLA2R1: <B>Cat. No. AMAB90772</B>: Immunohistochemical staining of human kidney with membranous nephropathy shows strong membranous immunoreactivity in renal glomeruli.

Anti-PLA2R1 antibody produced in rabbit - HPA012657 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-PLA2R1: <B>Cat. No. HPA012657</B>: Immunohistochemical staining of human lymph node shows strong cytoplasmic positivity in a subset of cells.

Anti-PLA2R1 antibody produced in goat - SAB2501500 from Sigma-Aldrich

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-PLA2R1 <B>Cat. No. SAB2501500</B>: (1 μg/mL) staining of Human Ileum lysate (35 μg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

PLA2R1-Antibody - AF2208a from Abgent, a WuXi AppTec company

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AF2208a (1 µg/ml) staining of Human Ileum lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

PLA2R1 antibody - orb20391 from Biorbyt

Prices $408.00
Sizes 100 μg
Host Goat
Clonality Polyclonal
orb20391 (1ug/ml) staining of Human Ileum lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

PLA2R1 Antibody (OAEB02012) - OAEB02012 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

PLA2R1 Antibody - abx103060 from Abbexa

Host Rabbit
Clonality Polyclonal

PLA2R1 / PLA2R antibody - AP10029PU-N from Acris Antibodies

Prices $310.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-PLA2R1 (AP10029PU-N)(1µg/ml) staining of Human Ileum lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

PLA2R1 / PLA2R antibody - AP55261PU-N from Acris Antibodies

Prices $480.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PLA2R Antibody - AC21-1909 from Abcore

Prices $359.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-PLA2R Antibody (AMCA) - AC21-1909-01 from Abcore

Prices $495.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-PLA2R Antibody (AP) - AC21-1909-02 from Abcore

Prices $505.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-PLA2R Antibody (APC) - AC21-1909-03 from Abcore

Prices $515.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-PLA2R Antibody (APC-Cy5.5) - AC21-1909-04 from Abcore

Prices $539.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-PLA2R Antibody (APC-Cy7) - AC21-1909-05 from Abcore

Prices $539.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-PLA2R Antibody (Avidin) - AC21-1909-06 from Abcore

Prices $519.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
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