PLA2R1

Gene Symbol	PLA2R1
Entrez Gene	22925
Alt Symbol	CLEC13C, PLA2-R, PLA2G1R, PLA2IR, PLA2R
Species	Human
Gene Type	protein-coding
Description	phospholipase A2 receptor 1, 180kDa
Other Description	180 kDa secretory phospholipase A2 receptor|C-type lectin domain family 13 member C|M-type receptor|phospholipase A2 receptor 1, 180kD|secretory phospholipase A2 receptor
Swissprots	D3DPB1 Q13019 Q15095 Q53R45 B2RTU9 Q53RR7 Q13018
Accessions	AAY24052 AAY24190 CCQ43399 EAX11391 EAX11392 EAX11393 Q13018 AI672072 AL598405 BC140823 AAI40824 BC144631 AAI44632 BF725498 BF805380 BP351340 BQ025507 BQ637466 BX485732 D30780 BAA06444 U17033 AAA70110 U17034 AAC50163 W15508 XM_005246392 XP_005246449 XM_005246393 XP_005246450 XM_005246395 XP_005246452 XM_006712369 XP_006712432 XM_011510820 XP_011509122 XM_011510821 XP_011509123 XR_922892 NM_001007267 NP_001007268 NM_001195641 NP_001182570 NM_007366 NP_031392
Function	Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2- IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2- IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow- derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPL
Subcellular Location	Isoform 2: Secreted {ECO:0000305}.
Tissue Specificity	Present in lung macrophage (at protein level). Highly expressed in kidney. Also expressed in pancreas, amnion, choriodecidua and placenta. Isoform 2 is expressed at much lower level. {ECO:0000269|PubMed:15611272, ECO:0000269|PubMed:7721806, ECO:0000269|PubMed:7925459, ECO:0000269|PubMed:9481783}.
Top Pathways	Phagosome, Tuberculosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PLA2R peptide - ab176432 from Abcam Category Peptide

PLA2R / PLA2R1 Antibody Blocking Peptide - LS-E27087 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PLA2R1 blocking peptide - GTX88257-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Dog, Bovine

Human PLA2R1 protein - orb244826 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human PLA2R1 protein - orb246853 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

PLA2R1 Immunizing peptide - orb15140 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

Human PLA2R1 Protein - abx068532 from Abbexa Category Protein Source E.coli Species Human

PLA2R Peptide - AC21-1909-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Phospholipase A2 Receptor 1 (PLA2R1), Human - 20-8853 from ARP American Research Products Category Protein Prices $579.00 Sizes 50 µg Source E.coli Species Human

PLA2R1 Peptide - 42-235P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

Recombinant Phospholipase A2 Receptor 1 (PLA2R1) - RPD851Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Phospholipase A2 Receptor 1 (PLA2R1) - RPD851Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Secretory phospholipase A2 receptor (PLA2R)... - pep0527 from Covalab Category Peptide Species Human

Recombinant Phospholipase A2 Receptor 1 (PLA2R1) - RPD851Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Secretory phospholipase A2 receptor(PLA2R1) ,partial - CSB-YP623780HU CSB-BP623780HU CSB-MP623780HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant Human Secretory phospholipase A2 receptor(PLA2R1) ,partial - CSB-EP623780HU from Cusabio Category Protein Source Yeast Species Human

PLA2R1 / PLA2R (transcript variant 2) - TP313576 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Phospholipase A2 Receptor 1 (PLA2R1), Recombinant Protein - MBS2018771 from MyBioSource Category Protein Prices $205.00, $450.00, $705.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

PLA2R1, Peptide - MBS425193 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Dog, Pig

Recombinant Human Secretory phospholipase A2 receptor - CSB-MP623780HU from Cusabio Category Protein Source Mammalian cell Species Human

PLA2R1 Recombinant Protein Antigen - NBP1-84449PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PLA2R1 Peptide, Human - M34GP11880H from Creative Peptides Category Peptide Source Synthetic. Species Human

PLA2R1 Recombinant Protein (OPCA02261) - OPCA02261 from Aviva Systems Biology Category Protein Prices $250.00 Sizes 50 µg Source Human

PLA2R1 Recombinant Protein (OPCA03010) - OPCA03010 from Aviva Systems Biology Category Protein Prices $250.00 Sizes 50 µg Source Human

PLA2R1 Recombinant Protein (OPCA03655) - OPCA03655 from Aviva Systems Biology Category Protein Prices $495.00 Sizes 20 µg Source Human

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