USP6

Gene Symbol	USP6
Entrez Gene	9098
Alt Symbol	HRP1, TRE17, TRE2, TRESMCR, Tre-2, USP6-short
Species	Human
Gene Type	protein-coding
Description	ubiquitin specific peptidase 6
Other Description	TBC1D3 and USP32 fusion|deubiquitinating enzyme 6|hyperpolymorphic gene 1|proto-oncogene TRE-2|ubiquitin carboxyl-terminal hydrolase 6|ubiquitin specific peptidase 6 (Tre-2 oncogene)|ubiquitin specific protease 6 (Tre-2 oncogene)|ubiquitin thioesterase 6|ubiquitin thiolesterase 6|ubiquitin-specific protease USP6|ubiquitin-specific-processing protease 6
Swissprots	Q86WP6 Q15634 P35125 Q8IWT4
Accessions	AAO21348 CAB94196 CCQ43264 P35125 AB449915 BAH16658 AY143550 AAN38838 BC029495 BC169209 BX647719 DQ586847 X63546 CAA45108 X63547 CAA45110 XM_011524049 XP_011522351 XM_011524050 XP_011522352 XM_011524051 XP_011522353 XM_011524052 XP_011522354 XM_011524053 XP_011522355 XM_011524054 XP_011522356 XM_011524055 XP_011522357 XM_011524056 XP_011522358 XM_011524057 XP_011522359 XM_011524058 XP_011522360 XM_011524059 XP_011522361 NM_005152 NM_001304284 NP_001291213 NM_004505 NP_004496
Function	Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6- dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation. {ECO:0000269|PubMed:15509780, ECO:0000269|PubMed:16127172, ECO:0000269|PubMed:20418905}.
Subcellular Location	Cell membrane. Cytoplasm. Endosome. Note=Localizes to the plasma membrane and to filamentous structures within the cell corresponding to ARF6 regulated tubular endosomes. Activation of RAC1 and CDC42 can direct the relocalization of USP6 to the plasma membrane in a manner that depends on the integrity of the actin cytoskeleton.
Tissue Specificity	Testis specific. Expressed in various cancer cell lines. {ECO:0000269|PubMed:12604796, ECO:0000269|PubMed:1565468}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

USP6 (N-18) - sc-48695 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

USP6/32 (D-11) - sc-377306 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

USP6/32 (K-14) - sc-48694 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

USP6/32 (H-300) - sc-98889 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Anti-USP6 antibody - ab4553 from Abcam Prices $370.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-USP6 antibody - ab56431 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-USP6 antibody - C-terminal - ab179751 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-USP6 / HRP1 Antibody (aa31-49) - LS-C3235 from LifeSpan Bioscience Prices $265.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-USP6 / HRP1 Antibody (aa773-786) - LS-C55661 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-USP6 / HRP1 Antibody (aa142-155) - LS-C154898 from LifeSpan Bioscience Prices $335.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-USP6 / HRP1 Antibody (aa971-1000, APC) - LS-C273193 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-USP6 / HRP1 Antibody (aa971-1000, AP) - LS-C273192 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-USP6 / HRP1 Antibody (aa971-1000, Biotin) - LS-C273194 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-USP6 / HRP1 Antibody (aa971-1000, Azide-free, HRP) - LS-C273196 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-USP6 / HRP1 Antibody (aa971-1000, PE) - LS-C273197 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-USP6 / HRP1 Antibody (aa971-1000, FITC) - LS-C273195 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-USP6 / HRP1 Antibody (N-Terminus, APC) - LS-C284105 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-USP6 / HRP1 Antibody (N-Terminus, Biotin) - LS-C284106 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-USP6 / HRP1 Antibody (N-Terminus, FITC) - LS-C284108 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-USP6 / HRP1 Antibody (N-Terminus, AP) - LS-C284107 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-USP6 / HRP1 Antibody (N-Terminus, Azide-free, HRP) - LS-C284109 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-USP6 / HRP1 Antibody (N-Terminus, PE) - LS-C284110 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-USP6 / HRP1 Antibody (N-Terminus) - LS-C329044 from LifeSpan Bioscience Prices $425.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-USP6 / HRP1 Antibody (aa971-1000) - LS-C330281 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-USP6 / HRP1 Antibody (aa975-1024) - LS-C201734 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

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