USP6

Gene Symbol	USP6
Entrez Gene	9098
Alt Symbol	HRP1, TRE17, TRE2, TRESMCR, Tre-2, USP6-short
Species	Human
Gene Type	protein-coding
Description	ubiquitin specific peptidase 6
Other Description	TBC1D3 and USP32 fusion|deubiquitinating enzyme 6|hyperpolymorphic gene 1|proto-oncogene TRE-2|ubiquitin carboxyl-terminal hydrolase 6|ubiquitin specific peptidase 6 (Tre-2 oncogene)|ubiquitin specific protease 6 (Tre-2 oncogene)|ubiquitin thioesterase 6|ubiquitin thiolesterase 6|ubiquitin-specific protease USP6|ubiquitin-specific-processing protease 6
Swissprots	Q86WP6 Q15634 P35125 Q8IWT4
Accessions	AAO21348 CAB94196 CCQ43264 P35125 AB449915 BAH16658 AY143550 AAN38838 BC029495 BC169209 BX647719 DQ586847 X63546 CAA45108 X63547 CAA45110 XM_011524049 XP_011522351 XM_011524050 XP_011522352 XM_011524051 XP_011522353 XM_011524052 XP_011522354 XM_011524053 XP_011522355 XM_011524054 XP_011522356 XM_011524055 XP_011522357 XM_011524056 XP_011522358 XM_011524057 XP_011522359 XM_011524058 XP_011522360 XM_011524059 XP_011522361 NM_005152 NM_001304284 NP_001291213 NM_004505 NP_004496
Function	Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6- dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation. {ECO:0000269|PubMed:15509780, ECO:0000269|PubMed:16127172, ECO:0000269|PubMed:20418905}.
Subcellular Location	Cell membrane. Cytoplasm. Endosome. Note=Localizes to the plasma membrane and to filamentous structures within the cell corresponding to ARF6 regulated tubular endosomes. Activation of RAC1 and CDC42 can direct the relocalization of USP6 to the plasma membrane in a manner that depends on the integrity of the actin cytoskeleton.
Tissue Specificity	Testis specific. Expressed in various cancer cell lines. {ECO:0000269|PubMed:12604796, ECO:0000269|PubMed:1565468}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human USP6 peptide - ab23054 from Abcam Category Peptide Species Human

Human USP6 protein fragment - ab160339 from Abcam Category Protein Source Wheat germ Species Human

USP6 / HRP1 Antibody Blocking Peptide - LS-E25550 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

USP6 / HRP1 Antibody Blocking Peptide - LS-E27881 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human USP6 Protein - H00009098-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Goat anti USP6 antibody Immunizing peptide - orb66389 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

USP6 Peptide - AC21-0379-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

USP6 Peptide - AC21-2886-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

USP6 / TRE2 - H00009098-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

USP6 / TRE2 - H00009098-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

USP6 / TRE2 - H00220594-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

USP6 / TRE2 - H00220594-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

USP6 Peptide - 46-565P from ProSci Category Peptide Species Human

USP6 Peptide - 43-030P from ProSci Category Peptide

Recombinant Human USP6, GST-tagged - USP6-277H from Creative Biomart Category Protein Source wheat germ

Recombinant Human USP6, GST-tagged - USP6-154H from Creative Biomart Category Protein Source Insect cells Species Human

Recombinant Human Ubiquitin carboxyl-terminal hydrolase 6(USP6) ,partial - CSB-YP025747HU CSB-EP025747HU CSB-BP025747HU CSB-MP025747HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

USP6, Peptide - MBS427902 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human

USP6/TRE2/TRE17, Peptide - MBS425422 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human

USP6-Antibody-N-term-Blocking-Peptide - BP2135a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

USP6-Antibody-C-term-Blocking-Peptide - BP2135b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

USP6 Peptide, Human - M34GP17198H from Creative Peptides Category Peptide Source Synthetic. Species Human

HRP1 Recombinant Protein (Mycobacterium tuberculosis) (OPCA05195) - OPCA05195 from Aviva Systems Biology Category Protein Species Mycobacterium

Recombinant Mycobacterium Tuberculosis HRP1 Protein (1-143 aa), His-SUMO-Myc-tagged - HRP1-2199M from Creative Biomart Category Protein Source E. coli Species Mycobacterium

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