| Gene Symbol |
MUC6
|
| Entrez Gene |
4588
|
| Alt Symbol |
MUC-6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mucin 6, oligomeric mucus/gel-forming
|
| Other Description |
gastric mucin-6|mucin-6
|
| Swissprots |
Q8N8I1 Q4L207 Q6W4X9 Q8NAK1 Q2TUQ5 Q14394 O15329
|
| Accessions |
AAQ86940 AAR14188 AAS76674 AFG72983 AFG72984 AFG72985 AFG72986 Q6W4X9 AK092533 AK096772 BAC04860 AK098503 AY312160 AAQ82434 AY458429 AAS13634 U97698 AAC51370 XM_006725532 XP_006725595 XM_011547747 XP_011546049 NM_005961 NP_005952
|
| Function |
May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis. {ECO:0000269|PubMed:10209489, ECO:0000269|PubMed:10330458, ECO:0000269|PubMed:11988092}.
|
| Subcellular Location |
Secreted.
|
| Tissue Specificity |
Expressed in the regenerative zone of gastric antrum, gastric body mucosa and gastric incisura mucosa. Expressed in the deeper mucous glands of gastric antrum. Overexpressed in Helicobacter pylori infected gastric epithelium. Highly expressed in duodenal Brunner's glands, gall bladder, seminal vesicle, pancreatic centroacinar cells and ducts, and periductal glands of the common bile duct. {ECO:0000269|PubMed:10209489, ECO:0000269|PubMed:10330458, ECO:0000269|PubMed:11988092, ECO:0000269|PubMed:15280409, ECO:0000269|PubMed:9422745}.
|