Gene Symbol | FH |
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Entrez Gene | 2271 |
Alt Symbol | FMRD, HLRCC, LRCC, MCL, MCUL1 |
Species | Human |
Gene Type | protein-coding |
Description | fumarate hydratase |
Other Description | fumarase|fumarate hydratase, mitochondrial |
Swissprots | B1ANK7 P07954 |
Accessions | AAP57532 EAW70090 EAW70091 EAW70092 EAW70093 P07954 AA669797 AK312415 BAG35325 AW611924 BC003108 AAH03108 BC017444 AAH17444 BT009839 AAP88841 DA129148 EU176358 ABW03809 M15502 AAA52483 U48857 AAD00071 U59309 AAB66354 XM_011544132 XP_011542434 NM_000143 NP_000134 |
Function | Also acts as a tumor suppressor. |
Subcellular Location | Isoform Mitochondrial: Mitochondrion. |
Tissue Specificity | Expressed in red blood cells; underexpressed in red blood cells (cytoplasm) of patients with hereditary non- spherocytic hemolytic anemia of unknown etiology. {ECO:0000269|PubMed:22509282}. |
Top Pathways | Citrate cycle (TCA cycle), Renal cell carcinoma, Pyruvate metabolism, Carbon metabolism |
fumarate hydratase CRISPR/Cas9 KO Plasmid (h) - sc-401660 from Santa Cruz Biotechnology
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fumarate hydratase HDR Plasmid (h) - sc-401660-HDR from Santa Cruz Biotechnology
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fumarate hydratase Double Nickase Plasmid (h) - sc-401660-NIC from Santa Cruz Biotechnology
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fumarate hydratase Double Nickase Plasmid (h2) - sc-401660-NIC-2 from Santa Cruz Biotechnology
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fumarate hydratase CRISPR Activation Plasmid (h) - sc-401660-ACT from Santa Cruz Biotechnology
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fumarate hydratase CRISPR Activation Plasmid (h2) - sc-401660-ACT-2 from Santa Cruz Biotechnology
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fumarate hydratase Lentiviral Activation Particles (h) - sc-401660-LAC from Santa Cruz Biotechnology
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fumarate hydratase Lentiviral Activation Particles (h2) - sc-401660-LAC-2 from Santa Cruz Biotechnology
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fumarate hydratase siRNA (h) - sc-105377 from Santa Cruz Biotechnology
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fumarate hydratase shRNA Plasmid (h) - sc-105377-SH from Santa Cruz Biotechnology
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fumarate hydratase shRNA (h) Lentiviral Particles - sc-105377-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU137741 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8678 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8678 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01847 from Sigma-Aldrich
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FH siRNA (Human) - CRH1588 from Cohesion Biosciences
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Fumarase RNAi - H00002271-R01 from Novus Biologicals
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FH - MBS8230443 from MyBioSource
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FH shRNA Plasmid (Human) - CHH1588 from Cohesion Biosciences
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FH miRNA 3'UTR clone - MiUTR3H-00833 from Creative biogene
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