Gene Symbol | ETS1 |
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Entrez Gene | 2113 |
Alt Symbol | ETS-1, EWSR2, p54 |
Species | Human |
Gene Type | protein-coding |
Description | v-ets avian erythroblastosis virus E26 oncogene homolog 1 |
Other Description | Avian erythroblastosis virus E26 (v-ets) oncogene homolog-1|protein C-ets-1|v-ets avian erythroblastosis virus E2 oncogene homolog 1 |
Swissprots | Q16080 P14921 A9UL17 F5GYX9 Q96AC5 Q14278 Q6N087 |
Accessions | AAA52409 EAW67709 EAW67710 EAW67711 EAW67712 P14921 AK001630 AK291840 BAF84529 AK301405 BAG62940 AL832693 AY943926 AAY19514 BC017314 AAH17314 BG035366 BM468663 BP365215 BT019452 AAV38259 BT019453 AAV38260 BX640634 CAE45783 CA407336 CR542254 CAG47050 J04101 AAA52410 S53284 S67063 AAB28747 S87905 X14798 CAA32903 XM_011542649 XP_011540951 XM_011542650 XP_011540952 XM_011542651 XP_011540953 XM_011542652 XP_011540954 NM_001143820 NP_001137292 NM_001162422 NP_001155894 NM_005238 NP_005229 |
Function | Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion. {ECO:0000269|PubMed:10698492, ECO:0000269|PubMed:11909962, ECO:0000269|PubMed:15247905, ECO:0000269|PubMed:15592518}. |
Subcellular Location | Cytoplasm. Nucleus. Note=Delocalizes from nucleus to cytoplasm when coexpressed with isoform Ets-1 p27. |
Tissue Specificity | Highly expressed within lymphoid cells. Isoforms c-ETS-1A and Ets-1 p27 are both detected in all fetal tissues tested, but vary with tissue type in adult tissues. None is detected in brain or kidney. {ECO:0000269|PubMed:19377509, ECO:0000269|PubMed:20378371}. |
Top Pathways | Renal cell carcinoma, HTLV-I infection, Dorso-ventral axis formation |
Human ETS1 full length protein - ab114322 from Abcam
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Human ETS1 full length protein - ab172853 from Abcam
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Human ETS1 peptide - ab85825 from Abcam
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Human ETS1 protein fragment - ab158386 from Abcam
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ETS1 / ETS-1 Antibody Blocking Peptide - LS-E437 from LifeSpan Bioscience
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Recombinant Human Ets-1 Protein - H00002113-P01 from Novus Biologicals
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Recombinant Human Ets-1 Protein - H00002113-Q01 from Novus Biologicals
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ETS1-Antibody-N-term-Blocking-peptide - BP10718a from Abgent, a WuXi AppTec company
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FLIP peptide - GTX28129 from GeneTex
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FLIP peptide - GTX28456 from GeneTex
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FLIP peptide - GTX28457 from GeneTex
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ETS1 Protein (OPPA01394) - OPPA01394 from Aviva Systems Biology
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Human ETS1 R protein - orb163488 from Biorbyt
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Human ETS1 protein - orb81095 from Biorbyt
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ETS1 (phospho-Thr38) Blocking Peptide - abx062594 from Abbexa
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ETS1 - H00002113-P01-10 from Acris Antibodies
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ETS1 - H00002113-P01-25 from Acris Antibodies
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ETS1 - H00002113-Q01-10 from Acris Antibodies
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ETS1 - H00002113-Q01-25 from Acris Antibodies
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Recombinant Human ETS1/P54 - 230-00235-10 from RayBiotech
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Recombinant Human ETS1/P54 - 230-00235-50 from RayBiotech
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Recombinant Human ETS1/P54 - 230-00235-100 from RayBiotech
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ETS1, Human, Recombinant - 19-CF51 from ARP American Research Products
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ETS1 fusion protein - Ag2127 from Proteintech Group
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ETS1 Human - PRPS-508 from NeoScientific
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