| Gene Symbol |
INIP
|
| Entrez Gene |
58493
|
| Alt Symbol |
C9orf80, HSPC043, MISE, SOSSC, SSBIP1, hSSBIP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
INTS3 and NABP interacting protein
|
| Other Description |
INTS3- and NABP-interacting protein|SOSS complex subunit C|SOSS-C|SSB-interacting protein 1|hSSB-interacting protein 1|minute INTS3/hSSB-associated element|sensor of single-strand DNA complex subunit C|sensor of ssDNA subunit C|single-stranded DNA-binding protein-interacting protein 1
|
| Swissprots |
Q9P090 Q96E04 Q5VWJ7 Q9NRY2
|
| Accessions |
EAW59113 Q9NRY2 AF161409 AAF28969 AF161411 AAF28971 AK000637 AK310007 BC013097 AAH13097 BC014881 AAH14881 BC065210 AAH65210 DQ892405 ABM83331 DQ895616 ABM86542 XM_006717208 XP_006717271 XM_011518891 XP_011517193 NM_021218 NP_067041
|
| Function |
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single- stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination- dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. {ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501}. Note=Localizes to nuclear foci following DNA damage.
|