Gene Symbol | INIP |
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Entrez Gene | 58493 |
Alt Symbol | C9orf80, HSPC043, MISE, SOSSC, SSBIP1, hSSBIP1 |
Species | Human |
Gene Type | protein-coding |
Description | INTS3 and NABP interacting protein |
Other Description | INTS3- and NABP-interacting protein|SOSS complex subunit C|SOSS-C|SSB-interacting protein 1|hSSB-interacting protein 1|minute INTS3/hSSB-associated element|sensor of single-strand DNA complex subunit C|sensor of ssDNA subunit C|single-stranded DNA-binding protein-interacting protein 1 |
Swissprots | Q9P090 Q96E04 Q5VWJ7 Q9NRY2 |
Accessions | EAW59113 Q9NRY2 AF161409 AAF28969 AF161411 AAF28971 AK000637 AK310007 BC013097 AAH13097 BC014881 AAH14881 BC065210 AAH65210 DQ892405 ABM83331 DQ895616 ABM86542 XM_006717208 XP_006717271 XM_011518891 XP_011517193 NM_021218 NP_067041 |
Function | Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single- stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination- dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. {ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501}. Note=Localizes to nuclear foci following DNA damage. |
C9orf80 CRISPR/Cas9 KO Plasmid (h) - sc-417935 from Santa Cruz Biotechnology
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C9orf80 HDR Plasmid (h) - sc-417935-HDR from Santa Cruz Biotechnology
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C9orf80 Double Nickase Plasmid (h) - sc-417935-NIC from Santa Cruz Biotechnology
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C9orf80 Double Nickase Plasmid (h2) - sc-417935-NIC-2 from Santa Cruz Biotechnology
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C9orf80 CRISPR Activation Plasmid (h) - sc-417935-ACT from Santa Cruz Biotechnology
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C9orf80 CRISPR Activation Plasmid (h2) - sc-417935-ACT-2 from Santa Cruz Biotechnology
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C9orf80 Lentiviral Activation Particles (h) - sc-417935-LAC from Santa Cruz Biotechnology
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C9orf80 Lentiviral Activation Particles (h2) - sc-417935-LAC-2 from Santa Cruz Biotechnology
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C9orf80 siRNA (h) - sc-92835 from Santa Cruz Biotechnology
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C9orf80 shRNA Plasmid (h) - sc-92835-SH from Santa Cruz Biotechnology
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C9orf80 shRNA (h) Lentiviral Particles - sc-92835-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU135081 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5228 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5228 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07606 from Sigma-Aldrich
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INIP siRNA (Human) - CRJ1723 from Cohesion Biosciences
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INIP - MBS827707 from MyBioSource
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shRNA set against Human C9orf80 (NM_021218.1) - SHH252989 from Creative biogene
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Human INIP siRNA - orb272224 from Biorbyt
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INIP shRNA Plasmid (Human) - CHJ1723 from Cohesion Biosciences
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INIP miRNA 3'UTR clone - MiUTR1H-01545 from Creative biogene
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