| Gene Symbol |
LOXL3
|
| Entrez Gene |
84695
|
| Alt Symbol |
LOXL
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
lysyl oxidase-like 3
|
| Other Description |
lysyl oxidase homolog 3|lysyl oxidase-like protein 3
|
| Swissprots |
Q96RS1 Q6IPL7 D6W5J1 Q2EHP2 P58215
|
| Accessions |
AAX93223 CCQ43775 EAW99615 EAW99616 P58215 AF282619 AAK51671 AF284815 AAK91134 AF311313 AAK63205 AK309474 AK309478 BC033130 AAH33130 BC071865 AAH71865 DA554977 DQ378059 ABD23013 XM_011533134 XP_011531436 NM_001289164 NP_001276093 NM_001289165 NP_001276094 NM_032603 NP_115992
|
| Function |
Both isoforms function as amine oxidases toward elastin and different types of collagens. Isoform 1 shows the highest activity toward collagen type VIII, while Isoform 2 presents the highest activity toward collagen type IV. {ECO:0000269|PubMed:17018530}.
|
| Subcellular Location |
Isoform 1: Secreted, extracellular space {ECO:0000305}.
|
| Tissue Specificity |
Isoform 1 ia predominantly detected in the heart, placenta, lung, and small intestine, while isoform 2 is more highly detected in the kidney, pancreas, spleen, and thymus, and is absent in lung. {ECO:0000269|PubMed:17018530}.
|
![Western Blot: LOXL3 Overexpression Lysate (Adult Normal) [NBP2-05987] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for LOXL3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2006_LOXL3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-05987-img0001.jpg)