WDFY3

Gene Symbol WDFY3
Entrez Gene 23001
Alt Symbol ALFY, ZFYVE25
Species Human
Gene Type protein-coding
Description WD repeat and FYVE domain containing 3
Other Description WD repeat and FYVE domain-containing protein 3|autophagy-linked FYVE protein
Swissprots Q8N1T2 Q4W5K5 Q9Y2J7 Q8NAV6 Q96D33 Q8IZQ1 Q96N85 Q6P0Q5 Q96BS7
Accessions AAY40903 EAX05952 EAX05953 EAX05954 EAX05955 EAX05956 Q8IZQ1 AB023210 BAA76837 AF131845 AF538685 AAN15137 AI393222 AI962188 AK055806 BAB71020 AK092019 AK092394 AK094910 BAC04455 BC013377 AAH13377 BC015214 AAH15214 BC065502 AAH65502 BC119633 AAI19634 BC148294 AAI48295 BC148298 AAI48299 BC150246 AAI50247 BE221984 BM676710 BQ003872 BX648077 BX648153 EF491804 EF491819 HQ447113 ADQ31600 XM_005262858 XP_005262915 XM_011531757 XP_011530059 XM_011531758 XP_011530060 XM_011531759 XP_011530061 XM_011531760 XP_011530062 XM_011531761 XP_011530063 XM_011531762 XP_011530064 XM_011531763 XP_011530065 XM_011531764 XP_011530066 XM_011531765 XP_011530067 XM_011531766 XP_011530068 XM_011531767 XP_011530069 NM_014991 NP_055806 NM_178583 NM_178585
Function Required for selective autophagy (aggrephagy) but not for autophagic degradation of bulk cytospol in response to starvation. Involved in the formation and degradation of cytoplasmic polyubiquitin-containing bodies (p62 bodies, ALIS/aggresome-like induced structures). May play a role as adaptor or scaffolding protein by promoting the association of the E3-like ligase ATG12-ATG5-ATG16L and LC3 to ubiquitinated target substrate. The association with GABARAP is required for its recruitment to LC3B-positive p62 bodies suggesting a role in targeting certain p62 structures for clearance. Involved in midbody ring degradation. {ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20417604, ECO:0000269|PubMed:24128730}.
Subcellular Location Nucleus membrane. Cytoplasm. Nucleus, PML body. Membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes with autophagic structures in starved cells. Shuttles between nucleus and cytoplasm; translocation from the nucleus to cytoplasmic polyubiquitin-containing bodies upon cellular stress is dependent on SQSTM1.
Tissue Specificity Ubiquitous. Expressed in osteoclast and their mononuclear precursors (at protein level). {ECO:0000269|PubMed:15292400, ECO:0000269|PubMed:20971078}.

WDFY3 (H-300) - sc-135323 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

WDFY3 (N-15) - sc-162395 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
WDFY3 (N-15): sc-162395. Immunoperoxidase staining of formalin fixed, paraffin-embedded human kidney tissue showing cytoplasmic staining of cells in glomeruli and cells in tubules.

WDFY3 (Q-14) - sc-162396 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-WDFY3 antibody - ab84888 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human WDFY3 in a formalin-fixed paraffin-embedded section of human ovarian carcinomaby by Immunohistochemistry using ab84888 at a dilution of 1:250. Detection: DAB staining.

Anti-WDFY3 / ALFY Antibody (aa500-550) IHC-plus™ - LS-B12067 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-WDFY3 / ALFY Antibody (aa500-550) - LS-C286609 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human WDFY3 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-WDFY3 used at a dilution of 1:250.

Anti-WDFY3 / ALFY Antibody (clone 2F12) - LS-C139264 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2F12

Anti-WDFY3 / ALFY Antibody (aa506-555) - LS-C82642 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Fetal muscle lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

WDFY3 Antibody - NBP1-03332 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: WDFY3 Antibody [NBP1-03332] - Whole cell lysate from HeLa (5, 15 and 50 mcg for WB; 1 mg for IP, 20% of IP loaded) and 293T (T; 50 mcg) cells. NBP1-03332 used for WB at 1 mcg/ml (A and B) and used for IP at 3 mcg/mg lysate.

WDFY3 Antibody - 44440002 from Novus Biologicals

Prices $299.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ELISA: WDFY3 Antibody [44440002]

WDFY3 Antibody (2F12) - H00023001-M03 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2F12
Sandwich ELISA: WDFY3 Antibody (2F12) [H00023001-M03] - Detection limit for recombinant GST tagged WDFY3 is 0.3 ng/ml as a capture antibody.

WDFY3 Polyclonal Antibody - bs-9924R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-WDFY3 antibody produced in rabbit - SAB2102693 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-WDFY3: <B>Cat. No.SAB2102693</B>: WDFY3 in Fetal Muscle tissue lysate with WDFY3 antibody at 1.0 μg/mL.

Anti-WDFY3 antibody produced in rabbit - HPA048572 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-WDFY3: <B>Cat. No. HPA048572</B>: Immunohistochemical staining of human duodenum shows strong granular cytoplasmic positivity in glandular cells.

Monoclonal Anti-WDFY3, (N-terminal) antibody produced in mouse - SAB1403121 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2F12
<B>Immunoblotting</B><BR/>Monoclonal Anti-WDFY3: <B>Cat. No. SAB1403121</B>: Antibody concentration: 1 μg/mL. Specific band of ~72.3 kDa using immunogen protein lysate.

Anti-WDFY3 antibody produced in rabbit - AV50850 from Sigma-Aldrich

Prices $347.50, $347.50
Sizes 50 µg, 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Cell Type: fetal brain (<B>Cat. No. AV50850</B>).<BR/><B>Lanes</B><BR/>1. Antibody dilution (concentration) 1 μg/mL in cell type fetal brain

WDFY3 antibody - middle region (ARP50849_P050) - ARP50849_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

WDFY3 antibody - C-terminal region (ARP50850_P050) - ARP50850_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

WDFY3 antibody - 70R-21300 from Fitzgerald

Prices $375.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

WDFY3 antibody - 70R-9012 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

WDFY3 antibody (FITC) - orb3697 from Biorbyt

Prices $315.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal

WDFY3 antibody - 70R-9011 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

WDFY3 / ALFY antibody - 55009-1-AP from Acris Antibodies

Prices $270.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical of paraffin-embedded human breast cancer using 55009-1-AP(WDFY3 antibody) at dilution of 1:50 (under 10x lens)

WDFY3 / ALFY antibody - H00023001-M03 from Acris Antibodies

Prices $360.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2F12

WDFY3 Antibody - 30-669 from ProSci

Prices $315.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Antibody used in WB on Human Brain at 0.2-1 ug/ml.
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