WDFY3

Gene Symbol WDFY3
Entrez Gene 23001
Alt Symbol ALFY, ZFYVE25
Species Human
Gene Type protein-coding
Description WD repeat and FYVE domain containing 3
Other Description WD repeat and FYVE domain-containing protein 3|autophagy-linked FYVE protein
Swissprots Q8N1T2 Q4W5K5 Q9Y2J7 Q8NAV6 Q96D33 Q8IZQ1 Q96N85 Q6P0Q5 Q96BS7
Accessions AAY40903 EAX05952 EAX05953 EAX05954 EAX05955 EAX05956 Q8IZQ1 AB023210 BAA76837 AF131845 AF538685 AAN15137 AI393222 AI962188 AK055806 BAB71020 AK092019 AK092394 AK094910 BAC04455 BC013377 AAH13377 BC015214 AAH15214 BC065502 AAH65502 BC119633 AAI19634 BC148294 AAI48295 BC148298 AAI48299 BC150246 AAI50247 BE221984 BM676710 BQ003872 BX648077 BX648153 EF491804 EF491819 HQ447113 ADQ31600 XM_005262858 XP_005262915 XM_011531757 XP_011530059 XM_011531758 XP_011530060 XM_011531759 XP_011530061 XM_011531760 XP_011530062 XM_011531761 XP_011530063 XM_011531762 XP_011530064 XM_011531763 XP_011530065 XM_011531764 XP_011530066 XM_011531765 XP_011530067 XM_011531766 XP_011530068 XM_011531767 XP_011530069 NM_014991 NP_055806 NM_178583 NM_178585
Function Required for selective autophagy (aggrephagy) but not for autophagic degradation of bulk cytospol in response to starvation. Involved in the formation and degradation of cytoplasmic polyubiquitin-containing bodies (p62 bodies, ALIS/aggresome-like induced structures). May play a role as adaptor or scaffolding protein by promoting the association of the E3-like ligase ATG12-ATG5-ATG16L and LC3 to ubiquitinated target substrate. The association with GABARAP is required for its recruitment to LC3B-positive p62 bodies suggesting a role in targeting certain p62 structures for clearance. Involved in midbody ring degradation. {ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20417604, ECO:0000269|PubMed:24128730}.
Subcellular Location Nucleus membrane. Cytoplasm. Nucleus, PML body. Membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes with autophagic structures in starved cells. Shuttles between nucleus and cytoplasm; translocation from the nucleus to cytoplasmic polyubiquitin-containing bodies upon cellular stress is dependent on SQSTM1.
Tissue Specificity Ubiquitous. Expressed in osteoclast and their mononuclear precursors (at protein level). {ECO:0000269|PubMed:15292400, ECO:0000269|PubMed:20971078}.

WDFY3 CRISPR/Cas9 KO Plasmid (h) - sc-406364 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

WDFY3 HDR Plasmid (h) - sc-406364-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

WDFY3 Double Nickase Plasmid (h) - sc-406364-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

WDFY3 Double Nickase Plasmid (h2) - sc-406364-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

WDFY3 CRISPR Activation Plasmid (h) - sc-406364-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

WDFY3 CRISPR Activation Plasmid (h2) - sc-406364-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

WDFY3 Lentiviral Activation Particles (h) - sc-406364-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

WDFY3 Lentiviral Activation Particles (h2) - sc-406364-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

WDFY3 siRNA (h) - sc-89191 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

WDFY3 shRNA Plasmid (h) - sc-89191-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

WDFY3 shRNA (h) Lentiviral Particles - sc-89191-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

WDFY3 RNAi - H00023001-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

WDFY3 RNAi - H00023001-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU139991 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22800 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22800 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07971 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr07971

WDFY3 siRNA (Human) - CRH7922 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

WDFY3 RNAi - H00023001-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

WDFY3 - MBS8225627 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human WDFY3 (NM_014991.4) - SHH445848 from Creative biogene

Category siRNA
Species Reactivities Human

Human WDFY3 siRNA - orb268424 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

WDFY3 shRNA Plasmid (Human) - CHH7922 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

WDFY3 miRNA 3'UTR clone - MiUTR4H-TG09826 from Creative biogene

Species Reactivities Human
Search more