| Gene Symbol |
MTA1
|
| Entrez Gene |
9112
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
metastasis associated 1
|
| Other Description |
metastasis associated gene 1 protein|metastasis-associated protein MTA1
|
| Swissprots |
A5PLK4 Q96GI8 Q86SW2 Q8NFI8 Q13330
|
| Accessions |
EAW81918 EAW81919 EAW81920 EAW81921 EAW81922 EAW81923 Q13330 AB209348 BAD92585 AF508978 AAN01613 AW732089 BC006177 AAH06177 BC009443 AAH09443 BC142941 AAI42942 BE139515 BX248755 CAD66562 BX248776 CAD66583 DN997955 U35113 AAA78935 XM_011537301 XP_011535603 XM_011537302 XP_011535604 XM_011537303 XP_011535605 XM_011537304 XP_011535606 XM_011537305 XP_011535607 XM_011537306 XP_011535608 XM_011537307 XP_011535609 XM_011537308 XP_011535610 XM_011537309 XP_011535611 XM_011537310 XP_011535612 XM_011537311 XP_011535613 XM_011537312 XP_011535614 XM_011537313 XP_011535615 XM_011537314 XP_011535616 XM_011537315 XP_011535617 NM_001203258 NP_001190187 NM_004689 NP_004680
|
| Function |
Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator. As a part of the histone-deacetylase multiprotein complex (NuRD), regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA. In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A. Acts as a transcriptional coactivator of BCAS3, PAX5 and SUMO2, independent of the NuRD complex. Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3. Plays a role in the inflammatory responses, both as a target and as a component of the NF-kappa-B signaling and regulates a subset of proinflammatory cytokines such as IL1B, MIP2, and TNF. Regulates p53-dependent and -independent DNA repair processes following genotoxic stress. Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and M
|
| Subcellular Location |
Isoform Short: Cytoplasm.
|
| Tissue Specificity |
Widely expressed. High expression in brain, liver, kidney, and cardiac muscle, ovaries, adrenal glands and virgin mammary glands. Higher in tumors than in adjacent normal tissue from the same individual. Up-regulated in a wide variety of cancers including breast, liver, ovarian, and colorectal cancer and its expression levels are closely correlated with tumor aggressiveness and metastasis. {ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:24970816}.
|