| Gene Symbol |
RBCK1
|
| Entrez Gene |
10616
|
| Alt Symbol |
C20orf18, HOIL-1, HOIL1, PBMEI, PGBM1, RBCK2, RNF54, UBCE7IP3, XAP3, XAP4, ZRANB4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RanBP-type and C3HC4-type zinc finger containing 1
|
| Other Description |
HBV associated factor 4|HBV-associated factor 4|RBCC protein interacting with PKC1|RING finger protein 54|heme-oxidized IRP2 ubiquitin ligase 1|hepatitis B virus X-associated protein 4|ranBP-type and C3HC4-type zinc finger-containing protein 1|ubiquitin conjugating enzyme 7 interacting protein 3|ubiquitin-conjugating enzyme 7-interacting protein 3
|
| Swissprots |
Q9BYM9 Q86SL2 O95623 Q96BS3 Q9BYM8
|
| Accessions |
EAX10673 EAX10674 EAX10675 EAX10677 Q9BYM8 AB107766 BAC75409 AK297524 BAG59927 AK303357 BAG64417 AK309414 BC000983 BC014116 BC015219 AAH15219 BC016301 U67322 AAD00162 XM_005260645 XP_005260702 XM_011529137 XP_011527439 XM_011529138 XP_011527440 XM_011529139 XP_011527441 XM_011529140 XP_011527442 XR_430267 XR_937029 NM_006462 NP_006453 NM_031229 NP_112506 NM_031227 NM_031228
|
| Function |
E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome. Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF- kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF- RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin t
|