RBCK1

Gene Symbol	RBCK1
Entrez Gene	10616
Alt Symbol	C20orf18, HOIL-1, HOIL1, PBMEI, PGBM1, RBCK2, RNF54, UBCE7IP3, XAP3, XAP4, ZRANB4
Species	Human
Gene Type	protein-coding
Description	RanBP-type and C3HC4-type zinc finger containing 1
Other Description	HBV associated factor 4|HBV-associated factor 4|RBCC protein interacting with PKC1|RING finger protein 54|heme-oxidized IRP2 ubiquitin ligase 1|hepatitis B virus X-associated protein 4|ranBP-type and C3HC4-type zinc finger-containing protein 1|ubiquitin conjugating enzyme 7 interacting protein 3|ubiquitin-conjugating enzyme 7-interacting protein 3
Swissprots	Q9BYM9 Q86SL2 O95623 Q96BS3 Q9BYM8
Accessions	EAX10673 EAX10674 EAX10675 EAX10677 Q9BYM8 AB107766 BAC75409 AK297524 BAG59927 AK303357 BAG64417 AK309414 BC000983 BC014116 BC015219 AAH15219 BC016301 U67322 AAD00162 XM_005260645 XP_005260702 XM_011529137 XP_011527439 XM_011529138 XP_011527440 XM_011529139 XP_011527441 XM_011529140 XP_011527442 XR_430267 XR_937029 NM_006462 NP_006453 NM_031229 NP_112506 NM_031227 NM_031228
Function	E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome. Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF- kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF- RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin t

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RBCK1 full length protein - ab153104 from Abcam Category Protein Source Wheat germ Species Human

Human RBCK1 protein fragment - ab161073 from Abcam Category Protein Source Wheat germ Species Human

RBCK1 Antibody Blocking Peptide - LS-E6857 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RBCK1 Antibody Blocking Peptide - LS-E15853 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human RBCK1 Protein - H00010616-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RBCK1 Partial Recombinant Protein - H00010616-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

RBCK1 Peptide - P0874 from Novus Biologicals Category Peptide Species Human

RBCK1 Peptide - P0873 from Novus Biologicals Category Peptide Species Human

RBCK1-UBCE7IP3-Antibody-C-term-Blocking-peptide - BP2107b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RBCK1-UBCE7IP3-Antibody-N-term-Blocking-peptide - BP2107a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

C20ORF18 Blocking Peptide - 33R-1633 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

POLR2E protein (His tag) - 30R-2907 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

RBCK1 / RNF54 - H00010616-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RBCK1 / RNF54 - H00010616-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

RBCK1 / RNF54 - H00010616-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RBCK1 / RNF54 - H00010616-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RBCK1 fusion protein - ag13554 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

RBCK1 fusion protein - ag13598 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human RBCK1, GST-tagged - RBCK1-2203H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human RanBP-type and C3HC4-type zinc finger-containing protein 1(RBCK1) - CSB-YP880138HU CSB-EP880138HU CSB-BP880138HU CSB-MP880138HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

RBCK1 / RNF54 (transcript variant 2) - TP303906 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

RBCK1 Recombinant Protein Antigen - NBP1-88301PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

RBCK1-Blocking-Peptide-N-term - BP20236a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RBCK1 Peptide, Human - M34GP13033H from Creative Peptides Category Peptide Source Synthetic. Species Human

RanBP-type and C3HC4-type zinc finger-containing protein 1 (RBCK1), Recombinant Protein - MBS1331539 from MyBioSource Category Protein Prices $1,300.00, $1,300.00, $1,515.00, $1,515.00, $2,135.00, $2,135.00, $2,600.00, $2,600.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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