| Gene Symbol |
LSS
|
| Entrez Gene |
4047
|
| Alt Symbol |
OSC
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
|
| Other Description |
2,3-epoxysqualene--lanosterol cyclase|2,3-epoxysqualene-lanosterol cyclase|hOSC|lanosterol synthase|oxidosqualene--lanosterol cyclase
|
| Swissprots |
Q9UEZ1 Q8IYL6 G5E9Q9 B4DJZ9 D3DSN0 E9PEI9 P48449
|
| Accessions |
CAB42828 CAY34695 CBG17604 CBG17696 CBV30957 CBV31050 EAX09299 EAX09300 EAX09301 EAX09302 EAX09303 P48449 AA922470 AK092334 BAC03865 AK096769 BAC04859 AK098352 BAC05289 AK128839 BAC87638 AK226141 AK296313 BAG59011 AK312489 BAG35391 AY927524 BC035638 AAH35638 BM662957 BU728696 BX443698 D63807 BAA09875 DA333499 DQ891234 ABM82160 DQ894418 ABM85344 S81221 AAB36220 X87809 CAA61078 XM_006724004 XP_006724067 XM_011529564 XP_011527866 XM_011529565 XP_011527867 XM_011529566 XP_011527868 XM_011529567 XP_011527869 XR_937491 NM_001001438 NP_001001438 NM_001145436 NP_001138908 NM_001145437 NP_001138909 NM_002340 NP_002331
|
| Function |
Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. {ECO:0000269|PubMed:7639730}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:14766201, ECO:0000269|PubMed:15525992}; Peripheral membrane protein {ECO:0000269|PubMed:14766201, ECO:0000269|PubMed:15525992}.
|
| Top Pathways |
Steroid biosynthesis
|
