Gene Symbol | ORMDL2 |
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Entrez Gene | 29095 |
Alt Symbol | HSPC160, MST095, MSTP095, adoplin-2 |
Species | Human |
Gene Type | protein-coding |
Description | ORMDL sphingolipid biosynthesis regulator 2 |
Other Description | ORM1-like protein 2|expressed in normal aorta |
Swissprots | B2RA58 Q8NFX0 Q7Z4E5 Q53FV1 Q9P004 |
Accessions | EAW96840 Q53FV1 AB064961 BAC11712 AF161509 AAF29124 AF173375 AAQ13618 AF395705 AAM43504 AF395706 AAM43505 AF395707 AAM43506 AK223180 BAD96900 AK314046 BAG36755 AW339474 BC012543 AAH12543 BG750383 EU831753 ACE87271 EU831830 ACE86589 NM_014182 NP_054901 |
Function | Negative regulator of sphingolipid synthesis. {ECO:0000269|PubMed:20182505}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:12093374}; Multi-pass membrane protein {ECO:0000269|PubMed:12093374}. |
Tissue Specificity | Widely expressed. Expressed in adult and fetal heart, brain, lung, liver, skeletal muscle and kidney. Expressed in adult pancreas and placenta and in fetal spleen abd thymus. {ECO:0000269|PubMed:12093374}. |
ORMDL2 CRISPR/Cas9 KO Plasmid (h) - sc-403585 from Santa Cruz Biotechnology
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ORMDL2 HDR Plasmid (h) - sc-403585-HDR from Santa Cruz Biotechnology
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ORMDL2 Double Nickase Plasmid (h) - sc-403585-NIC from Santa Cruz Biotechnology
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ORMDL2 Double Nickase Plasmid (h2) - sc-403585-NIC-2 from Santa Cruz Biotechnology
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ORMDL2 CRISPR Activation Plasmid (h) - sc-403585-ACT from Santa Cruz Biotechnology
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ORMDL2 CRISPR Activation Plasmid (h2) - sc-403585-ACT-2 from Santa Cruz Biotechnology
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ORMDL2 Lentiviral Activation Particles (h) - sc-403585-LAC from Santa Cruz Biotechnology
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ORMDL2 Lentiviral Activation Particles (h2) - sc-403585-LAC-2 from Santa Cruz Biotechnology
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ORMDL2 siRNA (h) - sc-96102 from Santa Cruz Biotechnology
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ORMDL2 shRNA Plasmid (h) - sc-96102-SH from Santa Cruz Biotechnology
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ORMDL2 shRNA (h) Lentiviral Particles - sc-96102-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU154901 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16152 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16152 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06469 from Sigma-Aldrich
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ORMDL2 siRNA (Human) - CRH9187 from Cohesion Biosciences
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shRNA set against Human ORMDL2 (NM_014182.4) - SHH368536 from Creative biogene
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Human ORMDL2 siRNA - orb269689 from Biorbyt
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ORMDL2 shRNA Plasmid (Human) - CHH9187 from Cohesion Biosciences
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ORMDL2 miRNA 3'UTR clone - MiUTR1H-07391 from Creative biogene
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