Casp1
| Gene Symbol | Casp1 |
|---|---|
| Entrez Gene | 25166 |
| Alt Symbol | Ice, Il1bc |
| Species | Rat |
| Gene Type | protein-coding |
| Description | caspase 1 |
| Other Description | CASP-1|IL-1 beta-converting enzyme|IL-1BC|Interleukin 1beta converting enzyme|caspase-1|interleukin 1, beta, convertase|interleukin-1 beta convertase|interleukin-1 beta-converting enzyme|p45 |
| Swissprots | P43527 |
| Accessions | EDL85232 EDL85233 P43527 BC088098 D85899 BAB67770 FQ228818 S79676 AAB35431 U14647 AAA85812 U34621 AAC52259 NM_012762 NP_036894 |
| Function | Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm. |
| Top Pathways | Amyotrophic lateral sclerosis (ALS), NOD-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Pertussis, Influenza A |
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