| Gene Symbol |
Casp1
|
| Entrez Gene |
25166
|
| Alt Symbol |
Ice, Il1bc
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
caspase 1
|
| Other Description |
CASP-1|IL-1 beta-converting enzyme|IL-1BC|Interleukin 1beta converting enzyme|caspase-1|interleukin 1, beta, convertase|interleukin-1 beta convertase|interleukin-1 beta-converting enzyme|p45
|
| Swissprots |
P43527
|
| Accessions |
EDL85232 EDL85233 P43527 BC088098 D85899 BAB67770 FQ228818 S79676 AAB35431 U14647 AAA85812 U34621 AAC52259 NM_012762 NP_036894
|
| Function |
Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm.
|
| Top Pathways |
Amyotrophic lateral sclerosis (ALS), NOD-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Pertussis, Influenza A
|