| Gene Symbol | Ube2l3 |
|---|---|
| Entrez Gene | 22195 |
| Alt Symbol | C79827, UbcM4, Ubce7 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | ubiquitin-conjugating enzyme E2L 3 |
| Other Description | ubiquitin carrier protein L3|ubiquitin-conjugating enzyme 7|ubiquitin-conjugating enzyme E2 L3|ubiquitin-protein ligase L3 |
| Swissprots | P68037 |
| Accessions | AAB36018 AAD10128 EDK97452 P68037 AJ130961 CAA10265 AK007265 BAB24925 AK152522 BAE31282 AK159876 BAE35448 AK165620 BAE38300 AK167847 BAE39867 AK187045 AK189509 AK208192 BC049075 BC057959 BC093503 AAH93503 BC106149 AAI06150 X97042 CAA65755 XM_006522004 XP_006522067 NM_009456 NP_033482 |
| Function | Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PARK2 and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down- regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. |
| Top Pathways | Ubiquitin mediated proteolysis |