| Gene Symbol |
Ube2l3
|
| Entrez Gene |
22195
|
| Alt Symbol |
C79827, UbcM4, Ubce7
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin-conjugating enzyme E2L 3
|
| Other Description |
ubiquitin carrier protein L3|ubiquitin-conjugating enzyme 7|ubiquitin-conjugating enzyme E2 L3|ubiquitin-protein ligase L3
|
| Swissprots |
P68037
|
| Accessions |
AAB36018 AAD10128 EDK97452 P68037 AJ130961 CAA10265 AK007265 BAB24925 AK152522 BAE31282 AK159876 BAE35448 AK165620 BAE38300 AK167847 BAE39867 AK187045 AK189509 AK208192 BC049075 BC057959 BC093503 AAH93503 BC106149 AAI06150 X97042 CAA65755 XM_006522004 XP_006522067 NM_009456 NP_033482
|
| Function |
Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PARK2 and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down- regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
|
| Top Pathways |
Ubiquitin mediated proteolysis
|