Gene Symbol | NDUFA4 |
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Entrez Gene | 4697 |
Alt Symbol | CI-9k, CI-MLRQ, MLRQ |
Species | Human |
Gene Type | protein-coding |
Description | NDUFA4, mitochondrial complex associated |
Other Description | Complex I 9kDa subunit|NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa|NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4|NADH-ubiquinone oxidoreductase MLRQ subunit|complex I-MLRQ|cytochrome c oxidase subunit NDUFA4 |
Swissprots | O00483 Q6FHN5 A4D109 |
Accessions | EAL24297 EAW93630 EAW93631 EAW93632 O00483 AF201077 AAF09253 AK024837 AK130950 BC101794 AAI01795 BC101796 AAI01797 BC105295 AAI05296 BG623521 CR407618 CAG28546 CR541716 CAG46517 U94586 AAB52726 NM_002489 NP_002480 |
Function | Cytochrome c oxidase (COX, complex IV) is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. Required for complex IV maintenance. {ECO:0000269|PubMed:22902835}. |
Subcellular Location | Mitochondrion inner membrane {ECO:0000269|PubMed:23746447}; Peripheral membrane protein {ECO:0000269|PubMed:23746447}; Matrix side {ECO:0000269|PubMed:23746447}. |
Top Pathways | Alzheimer's disease, Huntington's disease, Non-alcoholic fatty liver disease (NAFLD), Oxidative phosphorylation |
NDUFA4 CRISPR/Cas9 KO Plasmid (h) - sc-418023 from Santa Cruz Biotechnology
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NDUFA4 HDR Plasmid (h) - sc-418023-HDR from Santa Cruz Biotechnology
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NDUFA4 Double Nickase Plasmid (h) - sc-418023-NIC from Santa Cruz Biotechnology
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NDUFA4 Double Nickase Plasmid (h2) - sc-418023-NIC-2 from Santa Cruz Biotechnology
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NDUFA4 CRISPR Activation Plasmid (h) - sc-418023-ACT from Santa Cruz Biotechnology
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NDUFA4 CRISPR Activation Plasmid (h2) - sc-418023-ACT-2 from Santa Cruz Biotechnology
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NDUFA4 Lentiviral Activation Particles (h) - sc-418023-LAC from Santa Cruz Biotechnology
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NDUFA4 Lentiviral Activation Particles (h2) - sc-418023-LAC-2 from Santa Cruz Biotechnology
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NDUFA4 siRNA (h) - sc-89744 from Santa Cruz Biotechnology
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NDUFA4 shRNA Plasmid (h) - sc-89744-SH from Santa Cruz Biotechnology
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NDUFA4 shRNA (h) Lentiviral Particles - sc-89744-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU058471 from Sigma-Aldrich
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MISSION® esiRNA - EHU106531 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15141 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15141 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03770 from Sigma-Aldrich
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NDUFA4 siRNA (Human) - CRH3112 from Cohesion Biosciences
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shRNA set against Human NDUFA4 (NM_002489.3) - SHH350544 from Creative biogene
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NDUFA4 shRNA Plasmid (Human) - CHH3112 from Cohesion Biosciences
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NDUFA4 miRNA 3'UTR clone - MiUTR3H-06302 from Creative biogene
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