| Gene Symbol | NSFL1C |
|---|---|
| Entrez Gene | 55968 |
| Alt Symbol | P47, UBX1, UBXD10, UBXN2C, dJ776F14.1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | NSFL1 (p97) cofactor (p47) |
| Other Description | NSFL1 cofactor p47|SHP1 homolog|UBX domain-containing protein 2C|p97 cofactor p47 |
| Swissprots | Q7Z533 Q5JXA5 Q9NVL9 A2A2L1 B2RD74 Q9UNZ2 Q5JXA4 Q9UI06 Q9H102 |
| Accessions | EAX10627 EAX10628 EAX10629 EAX10630 EAX10631 EAX10632 Q9UNZ2 AA948047 AF078856 AAD44488 AF086909 AAP97139 AF112211 AAF17199 AF283774 AK001511 BAA91731 AK023585 AK093845 BAG52771 AK128722 BAC87590 AK223334 BAD97054 AK223341 BAD97061 AK297403 BAG59842 AK315433 BAG37821 BC002801 AAH02801 BE795675 BQ007132 DB173022 DB202404 DQ893189 ABM84115 DQ896513 ABM87512 XM_006723592 XP_006723655 XM_006723593 XP_006723656 XM_006723594 XP_006723657 XM_011529300 XP_011527602 XM_011529301 XP_011527603 XM_011529302 XP_011527604 XM_011529303 XP_011527605 XM_011529304 XP_011527606 XM_011529305 XP_011527607 XM_011529306 XP_011527608 NM_001206736 NP_001193665 NM_016143 NP_057227 NM_018839 NP_061327 NR_038164 NM_182483 |
| Function | Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro). {ECO:0000250}. |
| Subcellular Location | Nucleus {ECO:0000250}. Golgi apparatus, Golgi stack {ECO:0000250}. Chromosome {ECO:0000250}. Note=Predominantly nuclear in interphase cells. Bound to the axial elements of sex chromosomes in pachytene spermatocytes. A small proportion of the protein is cytoplasmic, associated with Golgi stacks (By similarity). {ECO:0000250}. |
| Top Pathways | Protein processing in endoplasmic reticulum |