Gene Symbol | HIST2H2AA3 |
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Entrez Gene | 8337 |
Alt Symbol | H2A, H2A.2, H2A/O, H2A/q, H2AFO, H2a-615, HIST2H2AA |
Species | Human |
Gene Type | protein-coding |
Description | histone cluster 2, H2aa3 |
Other Description | H2A histone family, member O|histone 2, H2aa3|histone H2A type 2-A |
Swissprots | Q6FI13 P20670 B2R5F0 |
Accessions | AAA35945 AAN59957 CAI12562 EAW50859 Q6FI13 AK312163 BAG35097 BC001629 BC019308 BC096705 AAH96705 BC096739 AAH96739 BC098171 AAH98171 BC152787 AAI52788 CR536525 CAG38762 CR541872 CAG46670 L19779 AAC24465 NM_003516 NP_003507 |
Function | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
Subcellular Location | Nucleus. Chromosome. |
Top Pathways | Systemic lupus erythematosus, Alcoholism |
Histone cluster 2 H2AA3 CRISPR/Cas9 KO Plasmid (h) - sc-418081 from Santa Cruz Biotechnology
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Histone cluster 2 H2AA3 HDR Plasmid (h) - sc-418081-HDR from Santa Cruz Biotechnology
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Histone cluster 2 H2AA3 Double Nickase Plasmid (h) - sc-418081-NIC from Santa Cruz Biotechnology
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Histone cluster 2 H2AA3 Double Nickase Plasmid (h2) - sc-418081-NIC-2 from Santa Cruz Biotechnology
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Histone cluster 2 H2AA3 CRISPR Activation Plasmid (h) - sc-418081-ACT from Santa Cruz Biotechnology
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Histone cluster 2 H2AA3 CRISPR Activation Plasmid (h2) - sc-418081-ACT-2 from Santa Cruz Biotechnology
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Histone cluster 2 H2AA3 Lentiviral Activation Particles (h) - sc-418081-LAC from Santa Cruz Biotechnology
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Histone cluster 2 H2AA3 Lentiviral Activation Particles (h2) - sc-418081-LAC-2 from Santa Cruz Biotechnology
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Histone cluster 2 H2AA3 siRNA (h) - sc-105506 from Santa Cruz Biotechnology
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Histone cluster 2 H2AA3 shRNA Plasmid (h) - sc-105506-SH from Santa Cruz Biotechnology
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Histone cluster 2 H2AA3 shRNA (h) Lentiviral Particles - sc-105506-V from Santa Cruz Biotechnology
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H2A RNAi - H00008337-R01 from Novus Biologicals
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MISSION® esiRNA - EHU229801 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10105 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10105 from Sigma-Aldrich
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HIST2H2AA3 siRNA (Human) - CRH5457 from Cohesion Biosciences
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shRNA set against Human HIST2H2AA3 (NM_003516.2) - SHH312873 from Creative biogene
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Human HIST2H2AA4 siRNA - orb279118 from Biorbyt
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Human HIST2H2AA3 siRNA - orb265959 from Biorbyt
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HIST2H2AA3 shRNA Plasmid (Human) - CHH5457 from Cohesion Biosciences
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HIST2H2AA3 miRNA 3'UTR clone - MiUTR3H-01072 from Creative biogene
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