Gene Symbol | CA4 |
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Entrez Gene | 762 |
Alt Symbol | CAIV, Car4, RP17 |
Species | Human |
Gene Type | protein-coding |
Description | carbonic anhydrase IV |
Other Description | CA-IV|carbonate dehydratase IV|carbonic anhydrase 4|carbonic dehydratase IV |
Swissprots | B4DQA4 P22748 Q6FHI7 |
Accessions | AAA35625 AAA35626 EAW94361 EAW94362 EAW94363 P22748 AI990988 AK289715 BAF82404 AK298710 BAG60866 BC057792 AAH57792 BC069649 AAH69649 BC074768 AAH74768 CR541766 CAG46565 DA113846 HQ448032 ADQ32513 M83670 AAA35630 XM_005257639 XP_005257696 XM_011525183 XP_011523485 NM_000717 NP_000708 |
Function | Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid. {ECO:0000269|PubMed:15563508}. |
Subcellular Location | Cell membrane; Lipid-anchor, GPI-anchor. |
Tissue Specificity | Expressed in the endothelium of the choriocapillaris in eyes (at protein level). Not expressed in the retinal epithelium at detectable levels. {ECO:0000269|PubMed:15563508}. |
Top Pathways | Nitrogen metabolism, Proximal tubule bicarbonate reclamation |
CA4-Over-expression-Lysate - LY11708a from Abgent, a WuXi AppTec company
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CA4 293T Cell Transient Overexpression Lysate(Denatured) - H00000762-T01 from Acris Antibodies
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CA4 overexpression lysate - LY424546 from Acris Antibodies
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Carbonic Anhydrase IV/CA4 Overexpression Lysate (Denatured) - H00000762-T01 from Novus Biologicals
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Human Carbonic Anhydrase IV / CA4 CHO Cell Lysate (WB positive control) - 10472-H08SL-300 from Sino Biological
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Human Carbonic Anhydrase IV / CA4 HEK293 Cell Lysate (WB positive control) - 10472-H08HL-300 from Sino Biological
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Human CA4 CHO Transfected Lysate (positive control) (denatured) - orb175405 from Biorbyt
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Human CA4 Human Cells Transfected Lysate (positive control) (denatured) - orb173681 from Biorbyt
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Carbonic Anhydrase IV/CA4 Overexpression Lysate (Native) - NBP2-10691 from Novus Biologicals
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Panoply™ Human CA4 Knockdown Stable Cell Line - CSC-DC002232 from Creative biogene
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