Gene Symbol | CA4 |
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Entrez Gene | 762 |
Alt Symbol | CAIV, Car4, RP17 |
Species | Human |
Gene Type | protein-coding |
Description | carbonic anhydrase IV |
Other Description | CA-IV|carbonate dehydratase IV|carbonic anhydrase 4|carbonic dehydratase IV |
Swissprots | B4DQA4 P22748 Q6FHI7 |
Accessions | AAA35625 AAA35626 EAW94361 EAW94362 EAW94363 P22748 AI990988 AK289715 BAF82404 AK298710 BAG60866 BC057792 AAH57792 BC069649 AAH69649 BC074768 AAH74768 CR541766 CAG46565 DA113846 HQ448032 ADQ32513 M83670 AAA35630 XM_005257639 XP_005257696 XM_011525183 XP_011523485 NM_000717 NP_000708 |
Function | Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid. {ECO:0000269|PubMed:15563508}. |
Subcellular Location | Cell membrane; Lipid-anchor, GPI-anchor. |
Tissue Specificity | Expressed in the endothelium of the choriocapillaris in eyes (at protein level). Not expressed in the retinal epithelium at detectable levels. {ECO:0000269|PubMed:15563508}. |
Top Pathways | Nitrogen metabolism, Proximal tubule bicarbonate reclamation |
CA IV CRISPR/Cas9 KO Plasmid (h) - sc-404215 from Santa Cruz Biotechnology
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CA IV HDR Plasmid (h) - sc-404215-HDR from Santa Cruz Biotechnology
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CA IV Double Nickase Plasmid (h) - sc-404215-NIC from Santa Cruz Biotechnology
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CA IV Double Nickase Plasmid (h2) - sc-404215-NIC-2 from Santa Cruz Biotechnology
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CA IV CRISPR Activation Plasmid (h) - sc-404215-ACT from Santa Cruz Biotechnology
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CA IV CRISPR Activation Plasmid (h2) - sc-404215-ACT-2 from Santa Cruz Biotechnology
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CA IV Lentiviral Activation Particles (h) - sc-404215-LAC from Santa Cruz Biotechnology
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CA IV Lentiviral Activation Particles (h2) - sc-404215-LAC-2 from Santa Cruz Biotechnology
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CA IV siRNA (h) - sc-29867 from Santa Cruz Biotechnology
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CA IV shRNA Plasmid (h) - sc-29867-SH from Santa Cruz Biotechnology
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CA IV shRNA (h) Lentiviral Particles - sc-29867-V from Santa Cruz Biotechnology
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Carbonic Anhydrase IV/CA4 RNAi - H00000762-R01 from Novus Biologicals
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MISSION® esiRNA - EHU036241 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1788 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1788 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01339 from Sigma-Aldrich
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CA4 siRNA (Human) - CRH0530 from Cohesion Biosciences
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CA4 - MBS8207898 from MyBioSource
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shRNA set against Human CA4 (NM_000717.3) - SHH253065 from Creative biogene
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Human CA4 siRNA - orb261032 from Biorbyt
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CA4 shRNA Plasmid (Human) - CHH0530 from Cohesion Biosciences
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CA4 miRNA 3'UTR clone - MiUTR3H-00342 from Creative biogene
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