| Gene Symbol |
CPZ
|
| Entrez Gene |
8532
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
carboxypeptidase Z
|
| Other Description |
metallocarboxypeptidase Z
|
| Swissprots |
Q96MX2 O00520 Q66K79
|
| Accessions |
EAW82332 EAW82333 EAW82334 EAW82335 Q66K79 AI270606 AK056317 BAB71147 AK127844 BAG54585 AW139378 BC006393 BC018913 BC080539 AAH80539 BF993977 BX338482 CV026874 DA050438 DA698835 DA704214 U83411 AAB58911 NM_001014447 NP_001014447 NM_001014448 NP_001014448 NM_003652 NP_003643
|
| Function |
Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during prohormone processing. {ECO:0000269|PubMed:11766880, ECO:0000269|PubMed:12417617, ECO:0000269|PubMed:9099699}.
|
| Subcellular Location |
Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:10671522}.
|
| Tissue Specificity |
In placenta, it is present within invasive trophoblasts and in the surrounding extracellular space. Also present in amnion cells, but is not readily apparent in the extracellular matrix of this cell type. Present in normal pituitary gland and neoplastic pituitary gland (especially POMC-, GH- and PRL-producing adenomas) (at protein level). Widely expressed. {ECO:0000269|PubMed:10671522, ECO:0000269|PubMed:12417617, ECO:0000269|PubMed:9099699}.
|
![Western Blot: CPZ Overexpression Lysate (Adult Normal) [NBP2-08739] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CPZ.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/15718_CPZ%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-08739-img0001.jpg)