| Gene Symbol |
Rb1
|
| Entrez Gene |
19645
|
| Alt Symbol |
Rb, Rb-1, pRb
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
retinoblastoma 1
|
| Other Description |
pp105|retinoblastoma-associated protein
|
| Swissprots |
P13405 Q4VA62
|
| Accessions |
EDL35859 P13405 AK011246 BAB27493 AK132875 BAE21400 AK141028 BAE24548 AK146467 BAE27194 AK148403 BAE28533 AK204056 BC096525 AAH96525 DQ400415 ABD72475 M26391 AAA39964 XM_006518731 XP_006518794 XR_383150 XR_383151 NM_009029 NP_033055
|
| Function |
Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor compl
|
| Subcellular Location |
Nucleus.
|
| Tissue Specificity |
Expressed in the cell nuclei of renal tubules, hepathocytes and skeletal muscles. Colocalizes with RB1CC1 in various tissues. {ECO:0000269|PubMed:12095676}.
|
| Top Pathways |
Cell cycle, Prostate cancer, Glioma, Pancreatic cancer, Non-small cell lung cancer
|