Rb1

Gene Symbol Rb1
Entrez Gene 19645
Alt Symbol Rb, Rb-1, pRb
Species Mouse
Gene Type protein-coding
Description retinoblastoma 1
Other Description pp105|retinoblastoma-associated protein
Swissprots P13405 Q4VA62
Accessions EDL35859 P13405 AK011246 BAB27493 AK132875 BAE21400 AK141028 BAE24548 AK146467 BAE27194 AK148403 BAE28533 AK204056 BC096525 AAH96525 DQ400415 ABD72475 M26391 AAA39964 XM_006518731 XP_006518794 XR_383150 XR_383151 NM_009029 NP_033055
Function Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor compl
Subcellular Location Nucleus.
Tissue Specificity Expressed in the cell nuclei of renal tubules, hepathocytes and skeletal muscles. Colocalizes with RB1CC1 in various tissues. {ECO:0000269|PubMed:12095676}.
Top Pathways Cell cycle, Prostate cancer, Glioma, Pancreatic cancer, Non-small cell lung cancer

Rb CRISPR/Cas9 KO Plasmid (m) - sc-422610 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Rb HDR Plasmid (m) - sc-422610-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Rb Double Nickase Plasmid (m) - sc-422610-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Rb Double Nickase Plasmid (m2) - sc-422610-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Rb CRISPR Activation Plasmid (m) - sc-422610-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Rb CRISPR Activation Plasmid (m2) - sc-422610-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Rb Lentiviral Activation Particles (m) - sc-422610-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Rb Lentiviral Activation Particles (m2) - sc-422610-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Rb siRNA (m) - sc-29469 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

Rb shRNA Plasmid (m) - sc-29469-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

Rb shRNA (m) Lentiviral Particles - sc-29469-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MISSION® esiRNA - EMU029731 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN39944 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND39944 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

RB1 siRNA (Mouse) - CRM3421 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

RB1 - MBS8206723 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

Mouse RB1 siRNA - orb282897 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

RB1 shRNA Plasmid (Mouse) - CHM3421 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse
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