| Gene Symbol |
KNSTRN
|
| Entrez Gene |
90417
|
| Alt Symbol |
C15orf23, HSD11, SKAP, TRAF4AF1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
kinetochore-localized astrin/SPAG5 binding protein
|
| Other Description |
TRAF4 associated factor 1|TRAF4-associated factor 1|kinastrin|kinetochore-localized astrin-binding protein|kinetochore-localized astrin/SPAG5-binding protein|putative TRAF4-associated factor 1|small kinetochore associated protein|small kinetochore-associated protein|small kinetochore-associated protein, kinetochore-localized astrin-binding protein, TRAF4 associated factor 1
|
| Swissprots |
Q9Y448 Q6PJM0 Q32Q57 Q6P2S5 B4DXA7 Q86XB4 Q147U5 Q5ISJ0
|
| Accessions |
EAW92409 EAW92410 EAW92411 EAW92412 Q9Y448 AK027408 AK125765 AK298156 BAG60430 AK301887 BAG63319 AW156972 AY652615 AAT66172 BC004543 AAH04543 BC014060 AAH14060 BC021124 BC045739 AAH45739 BC064344 AAH64344 BC107802 AAI07803 BC118559 AAI18560 BC118639 AAI18640 DC396708 U81002 AAD24201 NM_001142761 NP_001136233 NM_001142762 NP_001136234 NM_033286 NP_150628
|
| Function |
Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase (PubMed:19667759). Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:19667759, PubMed:22110139). The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule- kinetochore attachments (PubMed:21402792). Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division (PubMed:23035123). May be involved in UV- induced apoptosis via its interaction with PRPF19; however, these results need additional evidences (PubMed:24718257). {ECO:0000269|PubMed:19667759, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:22110139, ECO:0000269|PubMed:23035123, ECO:0000305|PubMed:24718257}
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:24718257}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:19667759, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:22110139, ECO:0000269|PubMed:23035123}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:19667759}. Note=Colocalizes with microtubules around centrosomes in prophase and with the mitotic spindle at prometaphase and metaphase. From late prometaphase to anaphase, is highly concentrated on kinetochores. Located at the kinetochore-microtubule interface. The astrin (SPAG5)-kinastrin (SKAP) complex localizes to the microtubule plus ends (PubMed:23035123). {ECO:0000269|PubMed:19667759, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:22110139, ECO:0000269|PubMed:23035123}.
|
| Tissue Specificity |
Widely expressed, including in skin. {ECO:0000269|PubMed:25194279}.
|