KNSTRN

Gene Symbol KNSTRN
Entrez Gene 90417
Alt Symbol C15orf23, HSD11, SKAP, TRAF4AF1
Species Human
Gene Type protein-coding
Description kinetochore-localized astrin/SPAG5 binding protein
Other Description TRAF4 associated factor 1|TRAF4-associated factor 1|kinastrin|kinetochore-localized astrin-binding protein|kinetochore-localized astrin/SPAG5-binding protein|putative TRAF4-associated factor 1|small kinetochore associated protein|small kinetochore-associated protein|small kinetochore-associated protein, kinetochore-localized astrin-binding protein, TRAF4 associated factor 1
Swissprots Q9Y448 Q6PJM0 Q32Q57 Q6P2S5 B4DXA7 Q86XB4 Q147U5 Q5ISJ0
Accessions EAW92409 EAW92410 EAW92411 EAW92412 Q9Y448 AK027408 AK125765 AK298156 BAG60430 AK301887 BAG63319 AW156972 AY652615 AAT66172 BC004543 AAH04543 BC014060 AAH14060 BC021124 BC045739 AAH45739 BC064344 AAH64344 BC107802 AAI07803 BC118559 AAI18560 BC118639 AAI18640 DC396708 U81002 AAD24201 NM_001142761 NP_001136233 NM_001142762 NP_001136234 NM_033286 NP_150628
Function Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase (PubMed:19667759). Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:19667759, PubMed:22110139). The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule- kinetochore attachments (PubMed:21402792). Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division (PubMed:23035123). May be involved in UV- induced apoptosis via its interaction with PRPF19; however, these results need additional evidences (PubMed:24718257). {ECO:0000269|PubMed:19667759, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:22110139, ECO:0000269|PubMed:23035123, ECO:0000305|PubMed:24718257}
Subcellular Location Nucleus {ECO:0000269|PubMed:24718257}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:19667759, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:22110139, ECO:0000269|PubMed:23035123}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:19667759}. Note=Colocalizes with microtubules around centrosomes in prophase and with the mitotic spindle at prometaphase and metaphase. From late prometaphase to anaphase, is highly concentrated on kinetochores. Located at the kinetochore-microtubule interface. The astrin (SPAG5)-kinastrin (SKAP) complex localizes to the microtubule plus ends (PubMed:23035123). {ECO:0000269|PubMed:19667759, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:22110139, ECO:0000269|PubMed:23035123}.
Tissue Specificity Widely expressed, including in skin. {ECO:0000269|PubMed:25194279}.

C15orf23 (E-19) - sc-245337 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
C15orf23 (E-19): sc-245337. Western blot analysis of C15orf23 expression in IMR-32 nuclear extract.

C15orf23 (S-18) - sc-245336 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-TRAF4AF1 antibody - ab122769 from Abcam

Prices $443.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescent staining of Human cell line U-2 OS shows positivity in cytoplasm and cytoskeleton (microtubules). Recommended concentration of ab122769 1-4 µg/ml. Cells treated with PFA/Triton X-100.

Anti-TRAF4AF1 antibody - N-terminal - ab177321 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-TRAF4AF1 antibody - N-terminal (ab177321) at 1 µg/ml + MDA-MB-435S whole cell lysate at 10 µg

Anti-SKAP / HSD11 Antibody (aa151-200) - LS-C170641 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-SKAP / HSD11 Antibody (aa31-80) - LS-C170642 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

SKAP Antibody - NBP1-94007 from Novus Biologicals

Prices $129.00, $419.00
Sizes 25 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SKAP Antibody [NBP1-94007] - Analysis in human cell line A-431.

Anti-KNSTRN antibody produced in rabbit - HPA042027 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-C15orf23: <B>Cat. No. HPA042027</B>: Immunohistochemical staining of human kidney shows strong cytoplasmic positivity in tubular cells.

Anti-C15orf23 (151-165) antibody produced in rabbit - SAB1103031 from Sigma-Aldrich

Prices $298.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Lysate of HEK-293T cells overexpressing human C15orf23 was separated on SDS-PAGE, blotted with Anti-C15orf23 (151-165) (<B>Cat. No. SAB1103031</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate.<BR/><B>Lanes</B><BR/>1. Antibody dilution 1:1,000

C15orf23 Antibody - middle region (ARP69085_P050) - ARP69085_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

C15orf23 Antibody - N-terminal region (ARP69086_P050) - ARP69086_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-KNSTRN (aa 31-80) polyclonal antibody - DPABH-12376 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-KNSTRN (aa 85-169) polyclonal antibody - DPABH-21063 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

C15orf23-Antibody-N-terminal-region-AI15706 - AI15706 from Abgent, a WuXi AppTec company

Prices $293.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Host: Rabbit Target Name: C15orf23 Sample Tissue: MDA-MB-435S Whole Cell lysates Antibody Dilution: 1.0ug/ml

C15orf23 antibody - 26189-1-AP from Acris Antibodies

Prices $270.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal
HepG2 cells were subjected to SDS PAGE followed by western blot with 26189-1-AP( C15orf23 Antibody) at dilution of 1:1500

C15orf23 antibody - 26189-1-AP from Proteintech Group

Prices $279.00
Sizes con: 63 μg/150μl
Host Rabbit
Clonality Polyclonal
HepG2 cells were subjected to SDS PAGE followed by western blot with 26189-1-AP( C15orf23 Antibody) at dilution of 1:1500

KNSTRN - A9751 from NeoScientific

Prices $480.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

KNSTRN Polyclonal Antibody - A9751 from ABclonal

Prices $200.00, $480.00
Sizes 50 µl, 200 µl
Host Rabbit
Clonality Polyclonal

Rabbit anti-human Corticosteroid 11-beta-dehydrogenase isozyme 1 polyclonal Antibody - CSB-PA010763LA01HU from ARP American Research Products

Prices $299.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

C15orf23 Antibody - abx124845 from Abbexa

Host Rabbit
Clonality Polyclonal

KNSTRN antibody - TA333584 from Acris Antibodies

Prices $325.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Host: Rabbit; Target Name: C15orf23; Sample Tissue: HepG2 Whole Cell lysates; Antibody Dilution: 1.0 ug/ml.

KNSTRN antibody - TA333585 from Acris Antibodies

Prices $325.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Host: Rabbit; Target Name: C15orf23; Sample Tissue: MDA-MB-435S Whole Cell lysates; Antibody Dilution: 1.0 ug/ml.

Anti-C15ORF23 polyclonal antibody - CABT-BL556 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-C15orf23 Antibody A08791 - A08791 from Boster Bio

Prices $299.00
Sizes 1
Host Rabbit
Clonality Polyclonal

KNSTRN Polyclonal Antibody - A14306 from ABclonal

Prices $88.00, $130.00, $220.00, $380.00
Sizes 20 µl trial, 50 µl, 100 µl, 200 µl
Host Rabbit
Clonality Polyclonal
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