| Gene Symbol |
HMGCLL1
|
| Entrez Gene |
54511
|
| Alt Symbol |
bA418P12.1, er-cHL
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1
|
| Other Description |
3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic|3-hydroxymethyl-3-methylglutaryl-CoA lyase-like protein 1|3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1|endoplasmic reticulum 3-hydroxymethyl-3-methylglutaryl-CoA lyase|probable 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2
|
| Swissprots |
B3KNV0 F8W793 B7Z1S7 B1AQ42 Q8TB92 Q6ZSA9
|
| Accessions |
EAX04442 EAX04443 EAX04444 EAX04445 Q8TB92 AF131827 AAD20054 AK055075 BAG51462 AK127587 BAC87045 AK293856 BAH11613 AK294210 BAH11698 AK297191 BAH12520 AL137605 CAB70838 BC024194 AAH24194 DA508472 DB179645 HQ447228 ADQ31715 XM_011514700 XP_011513002 XM_011514701 XP_011513003 NM_001042406 NP_001035865 NM_001287741 NP_001274670 NM_001287746 NP_001274675 NM_001287753 NP_001274682 NM_019036 NP_061909 NR_109867 NR_109869
|
| Function |
Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy- 3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues. {ECO:0000269|PubMed:22847177, ECO:0000269|PubMed:22865860}.
|
| Subcellular Location |
Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein.
|
| Top Pathways |
Peroxisome, Synthesis and degradation of ketone bodies, Valine, leucine and isoleucine degradation, Butanoate metabolism
|
![Western Blot: HMGCLL1 Overexpression Lysate (Adult Normal) [NBL1-11618] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for HMGCLL1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8400_HMGCLL1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11618-img0002.jpg)