| Gene Symbol |
henmt1
|
| Entrez Gene |
550540
|
| Alt Symbol |
hen1, si:ch211-199m3.6, zgc:110175
|
| Species |
Zebrafish
|
| Gene Type |
protein-coding
|
| Description |
HEN1 methyltransferase homolog 1 (Arabidopsis)
|
| Other Description |
small RNA 2'-O-methyltransferase
|
| Swissprots |
Q5RH79 Q568P9
|
| Accessions |
Q568P9 BC092772 AAH92772 BC165189 AAI65189 XM_009294718 XP_009292993 NM_001017842 NP_001017842
|
| Function |
Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation and adenylation activities and subsequent degradation. Stabilization of piRNAs is essential for oocyte development. {ECO:0000269|PubMed:20859253}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:20859253}. Note=Component of the meiotic nuage, also named P granule, a germ- cell-specific organelle required to repress transposon activity during meiosis.
|
| Tissue Specificity |
Gonad-specific. {ECO:0000269|PubMed:20859253}.
|