IL4R

Gene Symbol IL4R
Entrez Gene 3566
Alt Symbol CD124, IL-4RA, IL4RA
Species Human
Gene Type protein-coding
Description interleukin 4 receptor
Other Description IL-4 receptor subunit alpha|IL4R nirs variant 1|interleukin-4 receptor alpha chain|interleukin-4 receptor subunit alpha
Swissprots Q9H188 Q9H187 Q96P01 B9EKU8 H3BSY5 Q9H183 Q9H186 P24394 Q9H185 B4E076 Q9H184 Q9H181 Q9H182
Accessions AAC23495 AAL12163 CAC20445 CAC20446 CAC20447 CAC20448 CAC20449 CAC20450 CAC20451 CAC20452 CAJ01243 EAW55750 P24394 AA838318 AB102798 BAD89389 AK223591 BAD97311 AK303255 BAG64338 AK314863 BAG37378 BC110343 BC136365 AAI36366 BC151131 AAI51132 BX479288 DA492909 EF173858 ABM53131 X52425 CAA36672 XM_005255308 XP_005255365 XM_006721043 XP_006721106 XM_011545825 XP_011544127 XM_011545826 XP_011544128 XM_011545827 XP_011544129 XM_011545828 XP_011544130 XM_011545829 XP_011544131 XM_011545830 XP_011544132 XM_011545831 XP_011544133 XM_011545832 XP_011544134 XM_011545833 XP_011544135 XM_011545834 XP_011544136 NM_000418 NP_000409 NM_001257406 NP_001244335 NM_001257407 NP_001244336 NM_001257997 NP_001244926 NM_001008699
Function Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. {ECO:0000269|PubMed:8124718}.
Subcellular Location Cell membrane; Single-pass type I membrane protein.
Tissue Specificity Isoform 1 and isoform 2 are highly expressed in activated T-cells.
Top Pathways Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Hematopoietic cell lineage, PI3K-Akt signaling pathway, Inflammatory bowel disease (IBD)

IL-4Rα (C-20) - sc-684 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IL-4Rα (C-20): sc-684. Western blot analysis of IL-4Rα expression in Ramos whole cell lysate.

IL-4Rα (E-1) - sc-165974 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IL-4Rα (E-1): sc-165974. Western blot analysis of IL-4Rα expression in NIH/3T3 whole cell lysate.

IL-4Rα (H-300) - sc-25473 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IL-4Rα (H-300): sc-25473. Western blot analysis of truncated IL-4Rα expression in non-transfected: sc-117752 (A) and mouse IL-4Rα transfected: sc-127006 (B) 293T whole cell lysates.

IL-4Rα (H-4) - sc-28361 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IL-4Rα (H-4): sc-28361. Western blot analysis of IL-4Rα expression in untreated Ramos (A), IL-4-induced Ramos (B), untreated Daudi (C) and IL-4-induced Daudi (D) whole cell lysates.

Anti-IL4R (phospho Y497) antibody - ab61099 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IL4R (phospho Y497) antibody (ab61099) at 1/500 dilutionLane 1 : Extracts from 293 cellsLane 2 : Extracts from 293 cells with immunizing phosphopeptide

Anti-IL4R antibody - ab131058 from Abcam

Prices $388.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IL4R antibody (ab131058) at 0.5 µg/mlLane 1 : A431 cell lysateLane 2 : SMMC cell lysateLane 3 : U87 cell lysateLane 4 : 293T cell lysate

Anti-IL4R antibody - ab203398 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human colon carcinoma tissue labeling IL4R with ab203398 at 1/200 dilution followed by conjugation to the secondary antibody and DAB staining.

Anti-IL4R antibody - ab50277 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-IL4R antibody - C-terminal - ab178792 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-IL4R antibody - C-terminal (ab178792) at 1 µg/ml + Human HCT15 whole cell lysate at 10 µgdeveloped using the ECL technique

Anti-IL4R / CD124 Antibody (aa677-691) - LS-C344214 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of lysates from 293T, A431 cell line (from left to right) with IL4R Antibody. Antibody was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35 ug per lane.

Anti-IL4R / CD124 Antibody (Extracellular Domain, CF) - LS-C70896 from LifeSpan Bioscience

Prices $605.00
Sizes 100 tst
Host Goat
Clonality Polyclonal

Anti-IL4R / CD124 Antibody (Extracellular Domain) - LS-C70895 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-IL4R / CD124 Antibody (Extracellular Domain) - LS-C89402 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-IL4R / CD124 Antibody (Extracellular Domain, clone 49/20) - LS-C11209 from LifeSpan Bioscience

Prices $470.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 49/20

Anti-IL4R / CD124 Antibody (Extracellular Domain, PE) - LS-C70897 from LifeSpan Bioscience

Prices $605.00
Sizes 100 tst
Host Goat
Clonality Polyclonal

Anti-IL4R / CD124 Antibody (Extracellular Domain) - LS-C122009 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-IL4R / CD124 Antibody (aa205-254) - LS-C199907 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL4R / CD124 Antibody (aa444-493) - LS-C292099 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL4R / CD124 Antibody (aa26-232, Biotin) - LS-C300802 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL4R / CD124 Antibody (aa26-232, FITC) - LS-C304982 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL4R / CD124 Antibody - LS-C308476 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-IL4R / CD124 Antibody - LS-C311273 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL4R / CD124 Antibody (Gly493) - LS-C177331 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of IL-4R (G493) pAb in extracts from A549 cells.

Anti-IL4R / CD124 Antibody (aa656-705) - LS-C187247 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human HCT15 Whole Cell. IL4R antibody dilution 1.0 ug/ml.

Anti-IL4R / CD124 Antibody (aa463-512) - LS-C117963 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of A549 cells, using IL-4R/CD124 (Ab-497) Antibody. The picture on the right is treated with the synthesized peptide.
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