| Gene Symbol |
WNK2
|
| Entrez Gene |
65268
|
| Alt Symbol |
NY-CO-43, P/OKcl.13, PRKWNK2, SDCCAG43
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
WNK lysine deficient protein kinase 2
|
| Other Description |
antigen NY-CO-43|mitogen-activated protein kinase kinase kinase|protein kinase lysine-deficient 2|protein kinase with no lysine 2|protein kinase, lysine deficient 2|serine/threonine-protein kinase WNK2|serologically defined colon cancer antigen 43
|
| Swissprots |
Q5VWF1 Q9Y3S1 Q9H3P4 Q9C0A3 Q8IY36 Q5VWF2
|
| Accessions |
EAW62857 EAW62858 EAW62859 EAW62860 Q9Y3S1 AB044546 BAB18648 AB051547 BAB21851 AF039702 AAC18051 AJ242724 CAB44308 AK000694 AK093910 AK096968 AK124314 AK310390 BC037965 AAH37965 HY151846 XM_005252137 XP_005252194 XM_005252140 XP_005252197 XM_005252141 XP_005252198 XM_005252144 XP_005252201 XM_011518926 XP_011517228 XM_011518927 XP_011517229 XM_011518928 XP_011517230 XM_011518929 XP_011517231 XM_011518930 XP_011517232 XM_011518931 XP_011517233 XM_011518932 XP_011517234 XM_011518933 XP_011517235 XM_011518934 XP_011517236 XM_011518935 XP_011517237 XM_011518936 XP_011517238 XM_011518937 XP_011517239 XM_011518938 XP_011517240 XM_011518939 XP_011517241 XM_011518940 XP_011517242 NM_001282394 NP_001269323 NM_006648 NP_006639
|
| Function |
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity. {ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:18593598, ECO:0000269|PubMed:21733846}.
|
| Subcellular Location |
Cytoplasm. Cell membrane.
|
| Tissue Specificity |
Expressed in various cancer cell lines (at protein level). Predominantly expressed in heart, brain, skeletal muscle and colon. {ECO:0000269|PubMed:11571656, ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:21733846}.
|