GEMIN8

Gene Symbol GEMIN8
Entrez Gene 54960
Alt Symbol FAM51A1
Species Human
Gene Type protein-coding
Description gem (nuclear organelle) associated protein 8
Other Description family with sequence similarity 51, member A1|gem-associated protein 8|gemin-8
Swissprots Q6ZV27 Q2LJ66 C4AMC4 Q9NWZ8
Accessions EAW98851 EAW98852 EAW98853 EAW98854 EAW98855 EAW98856 Q9NWZ8 AK000521 BAA91227 AK095002 AK125062 BAC86038 BC003607 AAH03607 BC014324 AAH14324 BC020785 AAH20785 BX386466 CR457241 CAG33522 DQ224033 ABB46495 JF432848 ADZ16065 XM_005274555 XP_005274612 XR_950464 XR_950465 XR_950466 XR_950467 NM_001042479 NP_001035944 NM_001042480 NP_001035945 NM_017856 NP_060326
Function The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. {ECO:0000269|PubMed:17023415, ECO:0000269|PubMed:18984161}.
Subcellular Location Nucleus, gem {ECO:0000269|PubMed:16434402}. Cytoplasm {ECO:0000269|PubMed:16434402}. Note=Found in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm.
Top Pathways RNA transport

Gemin8 (A-12) - sc-376419 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Gemin8 (A-12): sc-376419. Immunoperoxidase staining of formalin fixed, paraffin-embedded human adrenal gland tissue showing nuclear staining of glandular cells.

Gemin8 (B-6) - sc-376518 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Gemin8 (B-6): sc-376518. Western blot analysis of Gemin8 expression in COLO 320DM whole cell lysate.

Gemin8 (FL-242) - sc-68374 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Gemin8 (FL-242): sc-68374. Western blot analysis of Gemin8 expression in COLO 320DM whole cell lysate.

Gemin8 (M-238) - sc-68375 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Gemin8 (M-238): sc-68375. Western blot analysis of Gemin8 expression in non-transfected: sc-117752 (A) and mouse Gemin8 transfected: sc-120467 (B) 293T whole cell lysates.

Gemin8 (N-19) - sc-66380 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Gemin8 (P-17) - sc-66381 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Gemin8 (1F8) - sc-130669 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Gemin8 (1F8): sc-130669. Western blot analysis of Gemin8 expression in Rat 2 (A), C3H/10T1/2 (B), NIH/3T3 (C) and P19 (D) whole cell lysates.

Anti-Gemin 8 antibody [1F8] - ab46778 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1F8

Anti-Gemin 8 antibody - C-terminal - ab173740 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Gemin 8 antibody - C-terminal (ab173740) at 1/100 dilution + A549 cell lysate at 35 µg

Anti-GEMIN8 Antibody (aa212-239, AP) - LS-C235612 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GEMIN8 Antibody (aa212-239, APC) - LS-C235613 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GEMIN8 Antibody (aa212-239, Biotin) - LS-C235615 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GEMIN8 Antibody (aa212-239, FITC) - LS-C235616 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GEMIN8 Antibody (aa212-239, PE) - LS-C235617 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GEMIN8 Antibody (aa212-239, Azide-free, HRP) - LS-C249055 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GEMIN8 Antibody (aa212-239) - LS-C329567 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GEMIN8 Antibody (clone 4E11) - LS-C339735 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4E11
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY GEMIN8 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-GEMIN8.

Anti-GEMIN8 Antibody (clone 2F5) - LS-C339737 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2F5
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY GEMIN8 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-GEMIN8.

Anti-GEMIN8 Antibody (clone 1A8) - LS-C339740 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1A8
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY GEMIN8 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-GEMIN8.

Anti-GEMIN8 Antibody (aa213-239) - LS-C159725 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
GEMIN8 Antibody western blot of A549 cell line lysates (35 ug/lane). The GEMIN8 antibody detected the GEMIN8 protein (arrow).

Anti-GEMIN8 Antibody (clone 4B12) - LS-C339741 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4B12
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY GEMIN8 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-GEMIN8.

Anti-GEMIN8 Antibody (clone 5C8) - LS-C339742 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5C8
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY GEMIN8 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-GEMIN8.

Anti-GEMIN8 Antibody (clone 2G6) - LS-C339743 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2G6
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY GEMIN8 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-GEMIN8.

Anti-GEMIN8 Antibody (clone 5B12) - LS-C339783 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5B12
IHC of paraffin-embedded Carcinoma of Human pancreas tissue using anti-GEMIN8 mouse monoclonal antibody. (heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-GEMIN8 Antibody (clone 4F8) - LS-C339784 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4F8
IHC of paraffin-embedded Carcinoma of Human lung tissue using anti-GEMIN8 mouse monoclonal antibody. (heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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