GEMIN8

Gene Symbol GEMIN8
Entrez Gene 54960
Alt Symbol FAM51A1
Species Human
Gene Type protein-coding
Description gem (nuclear organelle) associated protein 8
Other Description family with sequence similarity 51, member A1|gem-associated protein 8|gemin-8
Swissprots Q6ZV27 Q2LJ66 C4AMC4 Q9NWZ8
Accessions EAW98851 EAW98852 EAW98853 EAW98854 EAW98855 EAW98856 Q9NWZ8 AK000521 BAA91227 AK095002 AK125062 BAC86038 BC003607 AAH03607 BC014324 AAH14324 BC020785 AAH20785 BX386466 CR457241 CAG33522 DQ224033 ABB46495 JF432848 ADZ16065 XM_005274555 XP_005274612 XR_950464 XR_950465 XR_950466 XR_950467 NM_001042479 NP_001035944 NM_001042480 NP_001035945 NM_017856 NP_060326
Function The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. {ECO:0000269|PubMed:17023415, ECO:0000269|PubMed:18984161}.
Subcellular Location Nucleus, gem {ECO:0000269|PubMed:16434402}. Cytoplasm {ECO:0000269|PubMed:16434402}. Note=Found in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm.
Top Pathways RNA transport

GEMIN8 cDNA (ANA10279) - ANA10279 from Aviva Systems Biology

Prices $189.00
Sizes 1 µg
Accession NM_001042479

GEMIN8 - MBS1278717 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC003607

Human GEMIN8 cDNA clone(NM_001042479.1) - CDFH007490 from Creative Biomart

Species Human
Accession NM_001042479.1

Human GEMIN8 cDNA clone(NM_001042480.1) - CDFH007491 from Creative Biomart

Species Human
Accession NM_001042480.1

Human GEMIN8 cDNA clone(NM_001042480.1) - CDFH007492 from Creative Biomart

Species Human
Accession NM_001042480.1

Human GEMIN8 ORF Clone(NM_017856.2) - CDCL164543 from Creative Biomart

Species Human
Accession NM_017856.2

Human GEMIN8 ORF Clone(NM_001042479.1) - CDCR344384 from Creative Biomart

Species Human
Accession NM_001042479.1

Human GEMIN8 ORF Clone(NM_001042479.1) - CDCR344385 from Creative Biomart

Species Human
Accession NM_001042479.1

Human GEMIN8 ORF Clone(NM_001042480.1) - CDCR344386 from Creative Biomart

Species Human
Accession NM_001042480.1

Human GEMIN8 ORF Clone(NM_001042480.1) - CDCR344387 from Creative Biomart

Species Human
Accession NM_001042480.1

Human GEMIN8 ORF Clone(NM_001042480.1) - CDCR344388 from Creative Biomart

Species Human
Accession NM_001042480.1

Human GEMIN8 ORF Clone(NM_001042479.1) - CDCR344384 from Creative biogene

Species Human

Human GEMIN8 ORF Clone(NM_001042480.1) - CDCR344386 from Creative biogene

Species Human

Human GEMIN8 ORF Clone (BC003607) - CDCS407105 from Creative biogene

Species Human
Accession Q9NWZ8

Human GEMIN8 cDNA Clone(NM_001042479.1) - CDFH007490 from Creative biogene

Species Human

Human GEMIN8 cDNA Clone(NM_001042480.1) - CDFH007491 from Creative biogene

Species Human

Human GEMIN8 cDNA Clone(NM_001042480.1) - CDFH007492 from Creative biogene

Species Human
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