| Gene Symbol |
CYB5R2
|
| Entrez Gene |
51700
|
| Alt Symbol |
B5R.2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cytochrome b5 reductase 2
|
| Other Description |
NADH-cytochrome b5 reductase 2|cytochrome b5 reductase b5R.2
|
| Swissprots |
Q9UF68 Q9BVA3 Q9UHJ0 Q6BCY4
|
| Accessions |
EAW68648 EAW68649 EAW68650 EAW68651 Q6BCY4 AA814725 AB209000 BAD92237 AF169802 AAF04811 AI342011 AK022556 AK290102 BAF82791 AK308543 AL133582 CAB63726 AY665398 AAT75296 BC001346 AAH01346 BF061336 BG495762 BG723242 BG772396 BM693762 BM968347 BQ431043 CB149369 DB460012 HY211860 XM_005252975 XP_005253032 XM_005252976 XP_005253033 XM_006718251 XP_006718314 XM_006718252 XP_006718315 XM_011520184 XP_011518486 XM_011520185 XP_011518487 NM_001302826 NP_001289755 NM_001302827 NP_001289756 NM_016229 NP_057313 NR_126508 NM_001001336
|
| Function |
NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction (By similarity). Responsible for NADH-dependent lucigenin chemiluminescence in spermatozoa by reducing both lucigenin and 2-[4-iodophenyl]-3-[4-nitrophenyl]-5-[2,4- disulfophenyl]-2H tetrazolium monosodium salt (WST-1). {ECO:0000250, ECO:0000269|PubMed:15858218}.
|
| Tissue Specificity |
Restricted expression. {ECO:0000269|PubMed:10611283}.
|
| Top Pathways |
Amino sugar and nucleotide sugar metabolism
|