Gene Symbol | CYB5R2 |
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Entrez Gene | 51700 |
Alt Symbol | B5R.2 |
Species | Human |
Gene Type | protein-coding |
Description | cytochrome b5 reductase 2 |
Other Description | NADH-cytochrome b5 reductase 2|cytochrome b5 reductase b5R.2 |
Swissprots | Q9UF68 Q9BVA3 Q9UHJ0 Q6BCY4 |
Accessions | EAW68648 EAW68649 EAW68650 EAW68651 Q6BCY4 AA814725 AB209000 BAD92237 AF169802 AAF04811 AI342011 AK022556 AK290102 BAF82791 AK308543 AL133582 CAB63726 AY665398 AAT75296 BC001346 AAH01346 BF061336 BG495762 BG723242 BG772396 BM693762 BM968347 BQ431043 CB149369 DB460012 HY211860 XM_005252975 XP_005253032 XM_005252976 XP_005253033 XM_006718251 XP_006718314 XM_006718252 XP_006718315 XM_011520184 XP_011518486 XM_011520185 XP_011518487 NM_001302826 NP_001289755 NM_001302827 NP_001289756 NM_016229 NP_057313 NR_126508 NM_001001336 |
Function | NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction (By similarity). Responsible for NADH-dependent lucigenin chemiluminescence in spermatozoa by reducing both lucigenin and 2-[4-iodophenyl]-3-[4-nitrophenyl]-5-[2,4- disulfophenyl]-2H tetrazolium monosodium salt (WST-1). {ECO:0000250, ECO:0000269|PubMed:15858218}. |
Tissue Specificity | Restricted expression. {ECO:0000269|PubMed:10611283}. |
Top Pathways | Amino sugar and nucleotide sugar metabolism |
CYB5R2 CRISPR/Cas9 KO Plasmid (h) - sc-412239 from Santa Cruz Biotechnology
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CYB5R2 HDR Plasmid (h) - sc-412239-HDR from Santa Cruz Biotechnology
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CYB5R2 Double Nickase Plasmid (h) - sc-412239-NIC from Santa Cruz Biotechnology
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CYB5R2 Double Nickase Plasmid (h2) - sc-412239-NIC-2 from Santa Cruz Biotechnology
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CYB5R2 CRISPR Activation Plasmid (h) - sc-412239-ACT from Santa Cruz Biotechnology
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CYB5R2 CRISPR Activation Plasmid (h2) - sc-412239-ACT-2 from Santa Cruz Biotechnology
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CYB5R2 Lentiviral Activation Particles (h) - sc-412239-LAC from Santa Cruz Biotechnology
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CYB5R2 Lentiviral Activation Particles (h2) - sc-412239-LAC-2 from Santa Cruz Biotechnology
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CYB5R2 siRNA (h) - sc-96980 from Santa Cruz Biotechnology
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CYB5R2 shRNA Plasmid (h) - sc-96980-SH from Santa Cruz Biotechnology
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CYB5R2 shRNA (h) Lentiviral Particles - sc-96980-V from Santa Cruz Biotechnology
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CYB5R2 RNAi - H00051700-R02 from Novus Biologicals
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MISSION® esiRNA - EHU146011 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6851 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6851 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02029 from Sigma-Aldrich
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CYB5R2 siRNA (Human) - CRH9906 from Cohesion Biosciences
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CYB5R2 RNAi - H00051700-R01 from Novus Biologicals
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CYB5R2 - MBS8240734 from MyBioSource
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shRNA set against Human CYB5R2 (NM_016229.3) - SHH272593 from Creative biogene
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shRNA set against Human CYB5R2(NM_016229.3) - SHG214281 from Creative biogene
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CYB5R2 shRNA Plasmid (Human) - CHH9906 from Cohesion Biosciences
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CYB5R2 miRNA 3'UTR clone - MiUTR1H-02595 from Creative biogene
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