| Gene Symbol |
AKIP1
|
| Entrez Gene |
56672
|
| Alt Symbol |
BCA3, C11orf17
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
A kinase (PRKA) interacting protein 1
|
| Other Description |
A-kinase-interacting protein 1|breast cancer associated gene 3|koyt binding protein 1|koyt binding protein 2|koyt binding protein 3|proline-rich protein BCA3
|
| Swissprots |
Q8TAC6 Q8TAE0 Q8TAD3 Q8NBS2 Q9NQ31
|
| Accessions |
AAM12865 AAM12866 AAM12867 CAB92290 CAF86919 EAW68614 EAW68615 EAW68616 Q9NQ31 AF493783 AAM12862 AF493784 AAM12863 AF493785 AAM12864 AF512007 AAM34785 AK075308 BAC11537 AK294506 BAG57722 AK294549 BAG57753 AW340643 BC030996 AAH30996 BM706322 BP355293 DB570956 HQ447743 ADQ32228 XM_006718264 XP_006718327 NM_001206646 NP_001193575 NM_001206647 NP_001193576 NM_001206648 NP_001193577 NM_020642 NP_065693 NR_045417 NR_045418 NM_001206645 NM_182901
|
| Function |
Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade. {ECO:0000269|PubMed:18178962, ECO:0000269|PubMed:20562110}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:15630084, ECO:0000269|PubMed:18178962}. Note=Locates to punctate spots.
|
| Tissue Specificity |
Expressed at high levels in adult heart and at lower levels in brain, testis, ovary and skeletal muscle. Up- regulated in some breast cancer cell lines. Isoform 1 and isoform 3 are expressed in fetal brain. {ECO:0000269|PubMed:12527432, ECO:0000269|PubMed:15630084}.
|