PRPF19

Gene Symbol	PRPF19
Entrez Gene	27339
Alt Symbol	NMP200, PRP19, PSO4, SNEV, UBOX4, hPSO4
Species	Human
Gene Type	protein-coding
Description	pre-mRNA processing factor 19
Other Description	PRP19/PSO4 homolog|PRP19/PSO4 pre-mRNA processing factor 19 homolog|nuclear matrix protein 200|nuclear matrix protein NMP200 related to splicing factor PRP19|pre-mRNA-processing factor 19|psoralen 4|senescence evasion factor
Swissprots	Q9UMS4
Accessions	EAW73904 EAW73905 Q9UMS4 AF086469 AJ131186 CAB51857 AL555169 AW673738 BC008719 AAH08719 BC018665 AAH18665 BC018698 AAH18698 DQ893003 ABM83929 DQ896249 ABM87248 NM_014502 NP_055317
Function	Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal complex (PubMed:20595234). Recruited to RNA polymerase II C-terminal domain (CTD) and the pre-mRNA, it may also couple the transcriptional and spliceosomal machineries (PubMed:21536736). The XAB2 complex, which contains PRPF19, is also involved in pre- mRNA splicing, transcription and transcription-coupled repair (PubMed:17981804). Beside its role in pre-mRNA splicing PRPF19, as part of the PRP19-CDC5L complex, plays a role in the DNA damage response/D
Subcellular Location	Nucleus {ECO:0000269|PubMed:11082287, ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:20176811}. Nucleus, nucleoplasm {ECO:0000269|PubMed:11082287}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:11082287}. Cytoplasm {ECO:0000269|PubMed:11435423}. Lipid droplet {ECO:0000250|UniProtKB:Q99KP6}. Note=Nucleoplasmic in interphase cells. Irregularly distributed in anaphase cells. In prophase cells, uniformly distributed, but not associated with condensing chromosomes. Found in extrachromosomal regions in metaphase cells. Mainly localized to the mitotic spindle apparatus when chromosomes segregate during anaphase. When nuclei reform during late telophase, uniformly distributed in daughter cells and displays no preferred association with decondensing chromatin. Recruited on damaged DNA at sites of double-strand break. {ECO:0000269|PubMed:11082287, ECO:0000269|PubMed:18263876}.
Tissue Specificity	Ubiquitous. Weakly expressed in senescent cells of different tissue origins. Highly expressed in tumor cell lines. {ECO:0000269|PubMed:10404385, ECO:0000269|PubMed:11082287, ECO:0000269|PubMed:11435423, ECO:0000269|PubMed:12960389, ECO:0000269|PubMed:16388800}.
Top Pathways	Ubiquitin mediated proteolysis, Spliceosome

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PRP19 full length protein - ab132149 from Abcam Category Protein Source Wheat germ Species Human

Human PRP19 full length protein - ab172187 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human PRP19 peptide - ab28710 from Abcam Category Peptide

PRPF19 / PRP19 Antibody Blocking Peptide - LS-E7623 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PRPF19 / PRP19 Antibody Blocking Peptide - LS-E15893 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PRPF19 / PRP19 Antibody Blocking Peptide - LS-E15892 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TGIF1 Antibody Blocking Peptide - LS-E1399 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TGIF1 Antibody Blocking Peptide - LS-E1400 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TGIF1 Antibody Blocking Peptide - LS-E3395 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TGIF1 Antibody Blocking Peptide - LS-E18488 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TGIF1 Antibody Blocking Peptide - LS-E8830 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PRP19 Protein - H00027339-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human PRP19 Protein - H00027339-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PRPF19-Antibody-N-term-Blocking-Peptide - BP4870a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PRPF19 Blocking Peptide - 33R-9720 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PRPF19 Blocking Peptide - 33R-7381 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PRPF19 Blocking Peptide - abx063826 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Pig

PRPF19 / NMP200 - H00027339-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PRPF19 / NMP200 - H00027339-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

PRPF19 / NMP200 - H00027339-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PRPF19 / NMP200 - H00027339-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PRPF19 / NMP200 Control Peptide - AP10103CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 250 µg

PRPF19 / NMP200 control peptide - AP10277CP-N from Acris Antibodies Category Peptide Prices $255.00 Sizes 100 µg

PRPF19 / NMP200 Control Peptide - AP10284CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 100 µg

PRPF19 fusion protein - ag7700 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

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