| Gene Symbol |
IFT81
|
| Entrez Gene |
28981
|
| Alt Symbol |
CDV-1, CDV-1R, CDV1, CDV1R, DV1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
intraflagellar transport 81
|
| Other Description |
carnitine deficiency-associated gene expressed in ventricle 1|carnitine deficiency-associated protein expressed in ventricle 1|intraflagellar transport 81 homolog|intraflagellar transport protein 81 homolog
|
| Swissprots |
Q8NB51 Q2YDY1 Q9BSV2 Q9UNY8 Q8WYA0
|
| Accessions |
EAW97897 EAW97898 EAW97899 EAW97900 EAW97901 Q8WYA0 AF078932 AAD48091 AF139540 AAP97269 AF250326 AAL50343 AF332010 AAO32947 AK000874 AK091549 BAC03690 AK291043 BAF83732 BC004536 AAH04536 BC005396 AAH05396 BC029349 AAH29349 BC108257 AAI08258 BP351086 HQ447321 ADQ31808 XM_011538232 XP_011536534 XM_011538233 XP_011536535 XM_011538234 XP_011536536 XR_429093 XR_944523 NM_001143779 NP_001137251 NM_014055 NP_054774 NM_031473 NP_113661
|
| Function |
Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region. Required for ciliogenesis. {ECO:0000269|PubMed:23990561}.
|
| Subcellular Location |
Cell projection, cilium {ECO:0000305|PubMed:23990561}.
|
| Tissue Specificity |
Highly expressed in testis, moderately in ovary, heart, liver, skeletal muscle, kidney and pancreas, low in prostate, brain, placenta and lung and not detected in spleen, thymus, small intestine and colon. Isoform CDV-1R is abundantly expressed in testis. {ECO:0000269|PubMed:12549821}.
|