| Gene Symbol | EIF2S3 |
|---|---|
| Entrez Gene | 1968 |
| Alt Symbol | EIF2, EIF2G, EIF2gamma, eIF-2gA |
| Species | Human |
| Gene Type | protein-coding |
| Description | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa |
| Other Description | eIF-2-gamma X|eIF-2gX|eukaryotic translation initiation factor 2 subunit 3|eukaryotic translation initiation factor 2 subunit gamma X|eukaryotic translation initiation factor 2G |
| Swissprots | P41091 B5BTZ4 |
| Accessions | CAA07331 EAW99010 EAW99011 EAW99012 P41091 AB451230 BAG70044 AB451353 BAG70167 AF274932 AI133612 AK222577 BAD96297 AK290397 BAF83086 AK312247 BAG35179 BC011945 BC019906 AAH19906 BF435665 CB150474 DQ891794 ABM82720 DQ894977 ABM85903 L19161 AAA19696 NM_001415 NP_001406 |
| Function | eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. |
| Top Pathways | RNA transport |