Gene Symbol | EIF2S3 |
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Entrez Gene | 1968 |
Alt Symbol | EIF2, EIF2G, EIF2gamma, eIF-2gA |
Species | Human |
Gene Type | protein-coding |
Description | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa |
Other Description | eIF-2-gamma X|eIF-2gX|eukaryotic translation initiation factor 2 subunit 3|eukaryotic translation initiation factor 2 subunit gamma X|eukaryotic translation initiation factor 2G |
Swissprots | P41091 B5BTZ4 |
Accessions | CAA07331 EAW99010 EAW99011 EAW99012 P41091 AB451230 BAG70044 AB451353 BAG70167 AF274932 AI133612 AK222577 BAD96297 AK290397 BAF83086 AK312247 BAG35179 BC011945 BC019906 AAH19906 BF435665 CB150474 DQ891794 ABM82720 DQ894977 ABM85903 L19161 AAA19696 NM_001415 NP_001406 |
Function | eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. |
Top Pathways | RNA transport |
eIF2S3 CRISPR/Cas9 KO Plasmid (h) - sc-406266 from Santa Cruz Biotechnology
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eIF2S3 HDR Plasmid (h) - sc-406266-HDR from Santa Cruz Biotechnology
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eIF2S3 Double Nickase Plasmid (h) - sc-406266-NIC from Santa Cruz Biotechnology
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eIF2S3 Double Nickase Plasmid (h2) - sc-406266-NIC-2 from Santa Cruz Biotechnology
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eIF2S3 CRISPR Activation Plasmid (h) - sc-406266-ACT from Santa Cruz Biotechnology
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eIF2S3 CRISPR Activation Plasmid (h2) - sc-406266-ACT-2 from Santa Cruz Biotechnology
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eIF2S3 Lentiviral Activation Particles (h) - sc-406266-LAC from Santa Cruz Biotechnology
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eIF2S3 Lentiviral Activation Particles (h2) - sc-406266-LAC-2 from Santa Cruz Biotechnology
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eIF2S3 siRNA (h) - sc-91300 from Santa Cruz Biotechnology
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eIF2S3 shRNA Plasmid (h) - sc-91300-SH from Santa Cruz Biotechnology
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eIF2S3 shRNA (h) Lentiviral Particles - sc-91300-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU108091 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7756 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7756 from Sigma-Aldrich
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EIF2S3 siRNA (Human) - CRH1362 from Cohesion Biosciences
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EIF2G RNAi - H00001968-R02 from Novus Biologicals
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EIF2S3 - MBS8241234 from MyBioSource
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Human EIF2S3 siRNA - orb261864 from Biorbyt
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EIF2S3 shRNA Plasmid (Human) - CHH1362 from Cohesion Biosciences
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