Gene Symbol | FBN2 |
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Entrez Gene | 2201 |
Alt Symbol | CCA, DA9, EOMD |
Species | Human |
Gene Type | protein-coding |
Description | fibrillin 2 |
Other Description | fibrillin 5|fibrillin-2 |
Swissprots | Q59ES6 B4DU01 P35556 |
Accessions | CCQ43160 CCQ43161 EAW62388 EAW62389 EAW62390 EAW62391 P35556 AB209735 BAD92972 AF193046 AAG22474 AK300440 BAG62163 BC040623 BF368029 BG009811 BX343658 CD243435 CN300888 CN300893 CN300894 CN300904 CN481490 GU014836 ACX32323 U03272 AAA18950 X62009 CAB56757 NM_001999 NP_001990 |
Function | Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2- containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively (By similarity). {ECO:0000250|UniProtKB:Q61555}. |
Subcellular Location | Secreted, extracellular space, extracellular matrix. |
Tissue Specificity | Expressed in fetal eye (18 weeks)in the retinal pigment epithelium (RPE), the choroid, Bruch's membrane and in the sclera. Not expressed in the neural retina. {ECO:0000269|PubMed:24899048}. |
fibrillin-2 (H-10) - sc-393968 from Santa Cruz Biotechnology
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fibrillin-2 (N-20) - sc-28136 from Santa Cruz Biotechnology
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Anti-Fibrillin 2 antibody - ab128026 from Abcam
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Anti-Fibrillin 2 antibody - ab53804 from Abcam
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Anti-FBN2 / Fibrillin 2 Antibody (aa1055-1067) - LS-C41892 from LifeSpan Bioscience
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Anti-FBN2 / Fibrillin 2 Antibody - LS-C121812 from LifeSpan Bioscience
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Anti-FBN2 / Fibrillin 2 Antibody (aa2881-2893) - LS-C54840 from LifeSpan Bioscience
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Anti-FBN2 / Fibrillin 2 Antibody (aa2876-2888) - LS-C54841 from LifeSpan Bioscience
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Anti-FBN2 / Fibrillin 2 Antibody (aa1055-1067) - LS-C129039 from LifeSpan Bioscience
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Anti-FBN2 / Fibrillin 2 Antibody (C-Terminus) - LS-C155095 from LifeSpan Bioscience
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Anti-FBN2 / Fibrillin 2 Antibody (aa896-1106, Biotin) - LS-C300767 from LifeSpan Bioscience
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Anti-FBN2 / Fibrillin 2 Antibody (aa896-1106, FITC) - LS-C303694 from LifeSpan Bioscience
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Anti-FBN2 / Fibrillin 2 Antibody (clone 1C2) - LS-C197199 from LifeSpan Bioscience
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Anti-FBN2 / Fibrillin 2 Antibody (aa896-1106) - LS-C293873 from LifeSpan Bioscience
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Anti-FBN2 / Fibrillin 2 Antibody IHC-plus⢠- LS-B6338 from LifeSpan Bioscience
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Anti-FBN2 / Fibrillin 2 Antibody (aa1550-1791) - LS-C314480 from LifeSpan Bioscience
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Fibrillin 2 Antibody - NBP1-88169 from Novus Biologicals
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Fibrillin 2 Antibody - 36200002 from Novus Biologicals
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Fibrillin 2 Antibody (1C2) - H00002201-M01 from Novus Biologicals
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Fibrillin 2 Polyclonal Antibody - bs-12166R from Bioss
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Fibrillin 2 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-12166R-A350 from Bioss
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Fibrillin 2 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-12166R-A488 from Bioss
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Fibrillin 2 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-12166R-A555 from Bioss
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Fibrillin 2 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-12166R-A647 from Bioss
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Fibrillin 2 Polyclonal Antibody, Cy3 Conjugated - bs-12166R-Cy3 from Bioss
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