FBN2

Gene Symbol	FBN2
Entrez Gene	2201
Alt Symbol	CCA, DA9, EOMD
Species	Human
Gene Type	protein-coding
Description	fibrillin 2
Other Description	fibrillin 5|fibrillin-2
Swissprots	Q59ES6 B4DU01 P35556
Accessions	CCQ43160 CCQ43161 EAW62388 EAW62389 EAW62390 EAW62391 P35556 AB209735 BAD92972 AF193046 AAG22474 AK300440 BAG62163 BC040623 BF368029 BG009811 BX343658 CD243435 CN300888 CN300893 CN300894 CN300904 CN481490 GU014836 ACX32323 U03272 AAA18950 X62009 CAB56757 NM_001999 NP_001990
Function	Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2- containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively (By similarity). {ECO:0000250|UniProtKB:Q61555}.
Subcellular Location	Secreted, extracellular space, extracellular matrix.
Tissue Specificity	Expressed in fetal eye (18 weeks)in the retinal pigment epithelium (RPE), the choroid, Bruch's membrane and in the sclera. Not expressed in the neural retina. {ECO:0000269|PubMed:24899048}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

fibrillin-2 CRISPR/Cas9 KO Plasmid (h) - sc-406714 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

fibrillin-2 HDR Plasmid (h) - sc-406714-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

fibrillin-2 Double Nickase Plasmid (h) - sc-406714-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

fibrillin-2 Double Nickase Plasmid (h2) - sc-406714-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

fibrillin-2 CRISPR Activation Plasmid (h) - sc-406714-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

fibrillin-2 CRISPR Activation Plasmid (h2) - sc-406714-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

fibrillin-2 Lentiviral Activation Particles (h) - sc-406714-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

fibrillin-2 Lentiviral Activation Particles (h2) - sc-406714-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

fibrillin-2 siRNA (h) - sc-45971 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

fibrillin-2 shRNA Plasmid (h) - sc-45971-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

fibrillin-2 shRNA (h) Lentiviral Particles - sc-45971-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Fibrillin 2 RNAi - H00002201-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU041791 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN8509 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8509 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09935 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr09935

FBN2 siRNA (Human) - CRH1536 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

FBN2 - MBS8219393 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

fibrillin-2 CRISPR/Cas9 KO Plasmid (h2) - sc-406714-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

fibrillin-2 HDR Plasmid (h2) - sc-406714-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

shRNA set against Human FBN2 (NM_001999.3) - SHH292749 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human FBN2(NM_001999.3) - SHH050491 from Creative biogene Category siRNA Species Reactivities Human

Human FBN2 siRNA - orb262038 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

FBN2 shRNA Plasmid (Human) - CHH1536 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

FBN2 miRNA 3'UTR clone - MiUTR1H-03534 from Creative biogene Species Reactivities Human

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